To use all functions of this page, please activate cookies in your browser.
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Ethyl methanesulfonate (EMS) is a mutagenic, teratogenic, and possibly carcinogenic organic compound with formula C3H8O3S. It produces random mutations in genetic material by nucleotide substitution; specifically by guanine alkylation. This typically produces only point mutations. It can induce mutations at a rate of 5x10-4 to 5x10-2 per gene without substantial killing. The ethyl group of EMS reacts with guanine in DNA, forming the abnormal base O-6-ethylguanine. During DNA replication, DNA polymerases that catalyze the process frequently place thymine, instead of cytosine, opposite O-6-ethylguanine. Following subsequent rounds of replication, the original G:C base pair can become an A:T pair. This changes the genetic information, is often harmful to cells, and can result in disease. Many mutagens cause a wide variety of cancers in humans.
Additional recommended knowledge
In the 1982 movie Blade Runner, replicant Roy Batty asks Dr. Eldon Tyrell about the possibility of extending his preprogrammed lifespan by changing his genetic code with "EMS recombination". He is informed that ethyl methanesulfonate is a potent mutagen and that a test subject was "dead before he left the table."
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ethyl_methanesulfonate". A list of authors is available in Wikipedia.|