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Endothelial progenitor cell
Endothelial progenitor cells are bone marrow-derived cells that circulate in the blood and have the ability to differentiate into endothelial cells, the cells that make up the lining of blood vessels. The process by which blood vessels are born de novo from endothelial progenitor cells is known as vasculogenesis. Most of vasculogenesis occurs in utero during embryologic development. Endothelial progenitor cells found in adults are thus related to angioblasts, which are the stem cells that form blood vessels during embryogenesis. Endothelial progenitor cells are thought to participate in pathologic angiogenesis such as that found in retinopathy and tumor growth. While angioblasts have been known to exist for many years, adult endothelial progenitor cells were only characterized in the 1990s after Asahara and colleagues published that a purified population of CD34-expressing cells isolated from the blood of adult mice could differentiate into endothelial cells in vitro.  As endothelial progenitor cells are originally derived from the bone marrow, it is thought that various cytokines, growth factors, and hormones cause them to be mobilized from the bone marrow and into the peripheral circulation where they ultimately are recruited to regions of angiogenesis .
Endothelial Progenitor Cell Markers
Relationship to Cardiovascular Outcomes
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Endothelial_progenitor_cell". A list of authors is available in Wikipedia.|