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Cyclopiazonic acid



Cyclopiazonic acid
Identifiers
CAS number
PubChem 65261
SMILES CC(=O)C1=C(N2C(C1=O)C3C(C2(C)C)CC4=C5C3=CNC5=CC=C4)O
Properties
Molecular formula C20H20N2O3
Molar mass 336.384 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Cyclopiazonic acid (CPA) is a toxic fungal secondary metabolite. Chemically, it is an indole tetramic acid.

Additional recommended knowledge

CPA was originally isolated from Penicillium cyclopium and subsequently from other P. cyclopium, Penicillium griseofulvum, Aspergillus flavus and Aspergillus versicolor.

Cyclopiazonic acid only appears to be toxic in high concentrations.

Biologically, Cyclopiazonic acid is a specific inhibitor of Ca2+-ATPase in the intracellular Ca2+ storage sites.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cyclopiazonic_acid". A list of authors is available in Wikipedia.
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