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Cilengitide

Cilengitide

Identifiers
CAS number	188968-51-6
PubChem	176873
MeSH	Cilengitide
Properties
Molecular formula	C₂₇H₄₀N₈O7
Molar mass	588.656 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for α_v integrines, which are important in angiogenesis (forming new blood vessels). Hence, it is investigated for treating cancer by inhibiting angiogenesis.^[1]^[2]

References

^ Burke P, DeNardo S, Miers L, Lamborn K, Matzku S, DeNardo G (2002). "Cilengitide targeting of α_vβ₃ integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts". Cancer Res 62 (15): 4263-72. PMID 12154028.
^ Goodman Simon L., Hoelzemann Guenter, Sulyok Gabor A. G., Kessler Horst (2002). "Nanomolar Small Molecule Inhibitors for α_vβ₆, α_vβ₅, and α_vβ₃ Integrins". Journal of Medicinal Chemistry 45 (5): 1045-51. PMID 11855984.