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CAS number 188968-51-6
PubChem 176873
MeSH Cilengitide
Molecular formula C27H40N8O7
Molar mass 588.656 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrines, which are important in angiogenesis (forming new blood vessels). Hence, it is investigated for treating cancer by inhibiting angiogenesis.[1][2]


  1. ^ Burke P, DeNardo S, Miers L, Lamborn K, Matzku S, DeNardo G (2002). "Cilengitide targeting of αvβ3 integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts". Cancer Res 62 (15): 4263-72. PMID 12154028.
  2. ^ Goodman Simon L., Hoelzemann Guenter, Sulyok Gabor A. G., Kessler Horst (2002). "Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 Integrins". Journal of Medicinal Chemistry 45 (5): 1045-51. PMID 11855984.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cilengitide". A list of authors is available in Wikipedia.
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