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Channel blockers are chemical substances, ranging from ions to complex organic molecules, that bind inside the pore of an ion channel and block the flow of ions through that channel. A subset of channel blockers, known as "open channel blockers" have access to their intra-channel binding site only when the channel is in the open configuration (i.e. in the configuration that conducts transmembrane ion flux). Open channel block is characterized by "flickery closings" in single-channel recordings.
Additional recommended knowledge
Some examples of:
Open channel blockers
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Channel_blockers". A list of authors is available in Wikipedia.|