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Bart De Strooper

Bart De Strooper is a Belgian molecular biologist and professor at the Katholieke Universiteit Leuven (Leuven, Belgium). He is head of the VIB Department of Molecular and Developmental Genetics, K.U.Leuven.

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Bart De Strooper obtained an MD at the Katholieke Universiteit Leuven in 1985 and a PhD in 1992. He did a Postdoc at the EMBL in Heidelberg Germany in 1994. He is VIB Group leader since 1999, and Scientific Director, Department of Molecular and Developmental Genetics since 2007.

His research interest are the secretases which are proteases which cleave the amyloid peptide from the amyloid precursor protein (APP). The amyloid peptide is the main constituent of the plaques in the brain in Alzheimer's Disease. Together with Christian Haass he received the Potamkin Prize in 2002.

References

De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F., Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein, Nature. 1998 Jan 22;391(6665):387-90.
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R., A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain, Nature. 1999 Apr 8;398(6727):518-22.