RNA

Companies RNA

Santa Cruz Biotechnology, Inc., USA

Santa Cruz Biotechnology, Inc. is focused on the ongoing development of research antibodies. It is our goal to continue to offer the broadest range of research reagents in the field. We provide superior, innovative primary antibodies and support products. We are the leading worldwide source of prod more

United States Biological Inc., USA

United States Biological is a primary brand for the Life Science Industry. We are committed to reducing the cost of research with value, integrity and a truly personal buying experience. We believe in answering all inquiries within a few hours of receipt. There is no voice mail at United States Biol more

Products RNA

Unique RNAi tools for powerful gene silencing in vitro and in vivo

Our pre-designed, customized or validated RNAi tools and services are dedicated to help life scientist achieve highly efficient gene silencing more

High Capacity Biological Sample Concentrator

For laboratories looking to concentrate larger numbers of biological samples presented in a range of different formats the miVac Quattro from Genevac is the perfect high capacity sample concentrator more

Merck´s innovative SeccoSept™ closure for dried solvents

In combination with the innovative and unique septum seal cap SeccoSept™ you also benefit from reliable quality and safe handling more

News RNA

• Tactics of new Middle East virus suggest treating by altering lung cells' response to infection
  

  A new virus that causes severe breathing distress and kidney failure elicits a distinctive airway cell response to allow it to multiply. Scientists studying the Human Coronavirus-Erasmus Medical Center, which first appeared April 2012 in the Middle East, have discovered helpful details about its str more

• Blockade of pathogen's metabolism
  

  In the search for new antibiotics, researchers are taking an unusual approach: They are developing peptides, short chains of protein building blocks that effectively inhibit a key enzyme of bacterial metabolism. Now, scientists at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) i more

• Pain reliever shows anti-viral activity against flu

  The over-the-counter anti-inflammatory drug naproxen may also exhibit antiviral activity against influenza A virus, according to a team of French scientists. New influenza vaccines must be developed annually, because the surface proteins they target mutate rapidly, the way cars used to get a whole n more

White papers RNA

• miRNA Extraction and Profiling on FFPE Samples
  

  RNA silencing is a mechanism of gene regulation whereby small double-stranded RNAs (dsRNAs) of 21-18 nucleotides in length cause mRNA degradation, mRNA translation, or chromatin modification. In the past years, more than 500 novel genes have been identified in animals and plants encoding small transcripts that can form small dsRNA hairpin structures. From these hairpin precursors, small 22-nt RNAs - so called microRNAs (miRNA) - are excised by dsRNA-specific endonucleases. The miRNAs are then integrated in ribonucleoprotein particles (RNPs). Most miRNAs in animals act by binding to partially complementary regions of the 3' untranslated region of their target mRNA, thereby blocking translation. more

• HelpCorner - Gene Silencing
  

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• New Application for the LightCycler® 480 System: qPCR-based microRNA-Profiling
  

  Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies and therefore represent a promising new class of biomarkers. Quantitative PCR-based technologies are emerging as the gold standard for miRNA profiling. Here, a commercially available miRNA assay was used to measure and compare the expression levels of 154 miRNAs of seven lymph node samples using the LightCycler® 480 Instrument and a competitor real-time PCR system. We observed highly similar results for 134 miRNAs (87%) and some larger deviations (20 ­miRNAs/13%). In addition to large-scale miRNA profiling, it is also possible to use the LightCycler® 480 System in the assessment of miRNA expression in small sample sizes. We have conclusively demonstrated that miR-205 can be detected in a dose-dependent manner in a dilution series of 50, 10, 5, and 1 cell(s) of the KU19-19 cell line. more

Publications RNA

• Gene Duplication Is Infrequent in the Recent Evolutionary History of RNA Viruses

  Gene duplication generates genetic novelty and redundancy and is a major mechanism of evolutionary change in bacteria and eukaryotes. To date, however, gene duplication has been reported only rarely in RNA viruses. Using a conservative BLAST approach we systematically screened for the presence of d more

• Identification of microRNA and bioinformatics target gene analysis in beef cattle intramuscular fat and subcutaneous fat

  microRNA (miRNA) are endogenous non-coding RNA that has been proposed play important roles in the formation of body fat. However, the differential expression of miRNA and the role of these miRNA in bovine intramuscular and subcutaneous fat tissue are still unknown. In this study, profile of differen more

• The 3′ UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse

  While FMR1 is silenced in Fragile X syndrome (FXS) patients carrying the full mutation, its expression is elevated (2–8 fold) in premutated individuals. These people may develop the Fragile X-associated Tremor/Ataxia syndrome (FXTAS), a late onset neurodegenerative disorder characterized by ataxia more

Market studies RNA

• Epigenetics R&D Pipeline - Histone Deacetylases (HDACs) Offer the Most Promising Targets and Outnumber Other Classes of Epigenetic Targets

  GBI Research, a leading business intelligence provider, has released its latest research, entitled “Epigenetics R&D Pipeline - Histone Deacetylases (HDACs) Offer the Most Promising Targets and Outnumber Other Classes of Epigenetic Targets”. The report is built using data and information sourced from more

• Gene Therapy Market to 2018 - Product Development Slowed by Clinical Failures, Close Regulatory Surveillance and High Compliance Standards

  GBI Research’s new report, “Gene Therapy Market to 2018 - Product Development Slowed by Clinical Failures, Close Regulatory Surveillance and High Compliance Standards”, provides in-depth analysis of the unmet needs, drivers and barriers that impact the global gene therapy market. The report analyzes more

• Illumina, Inc. (ILMN) - Financial and Strategic SWOT Analysis Review

  Illumina, Inc. (ILMN) - Financial and Strategic SWOT Analysis Review Summary Illumina, Inc. (Illumina) is a molecular diagnostics company that principally focuses on the research and development of DNA and RNA Assays. It is involved in the development, manufacture and marketing of integrated syste more

Websites RNA