Pathology

News Pathology

• Leica Biosystems To Acquire Aperio

  Leica Biosystems announced that an affiliate has entered into a definitive agreement to acquireAperio, a leading provider of ePathology solutions.Aperio will be integrated into Leica Biosystems. Together, the two businesses will leverage each other's strengths to grow and expand digital pathology in more

• Carl Zeiss Licences Digital Pathology from Olympus

  Carl Zeiss Microscopy GmbH and Olympus America Inc. have signed a nonexclusive worldwide licensing agreement allowing Carl Zeiss to access an extensive portfolio of patents held by Olympus in the field of digital pathology and virtual microscopy. The patents included in the licensing deal cover meth more

• China Medical Technologies and Leica Microsystems Announce Collaboration

  China Medical Technologies, Inc. (CMED) and Leica Biosystems, a division of Leica Microsystems, announced that they have established a sales, research and development collaboration to co-develop and market automated FISH kits to be used on the Leica BOND system. CMED will sell the Automated FISH Kit more

White papers Pathology

• cDNA Synthesis with the Transcriptor First Strand cDNA Synthesis Kit from Formalin-Fixed Paraffin-Embedded Tissue (FFPET) Samples
  

  Partial degradation of RNA is a common problem when working with FFPET samples. Semi-­quantitative RT-PCR assays amplifying the 5´- and 3´-end sequences of the housekeeping gene b-actin present a solution: calculating the ratio of the 3´- to 5´-amplicon allows ­assessment of RNA integrity. An important step for reproducible quantification is the reverse ­transcription reaction. The ­applicability of the new Transcriptor First Strand cDNA Synthesis Kit to partially degraded FFPET RNA was evaluated. The new kit is compared with the widely used First Strand cDNA Synthesis Kit for RT-PCR (AMV). Under modified reaction ­conditions (temperature, time) the kit reversely transcribes the FFPET samples with high ­efficiency. more

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to neuroblastoma cells exposed to bortezomib, a proteasome inhibitor in clinical use. It has been shown previously that neuroblastoma cell lines are prone to undergo apoptosis when treated with bortezomib, but the precise molecular mechanism has not been revealed. In addition to this, peripheral neuropathy is the main side effect of chemotherapy that includes bortezomib more

• Superiority of FuGENE® HD Transfection Reagent in Minimizing Non-Specific Cellular Interferon Responses
  

  Many viruses, including human cytomegalovirus (HCMV), encode for genes that can modulate or interfere with the ability of cells to mount an effective antiviral response to infection. Transfection of viral genes into cultures of mammalian cells is an important research tool to evaluate the function of viral gene products. We utilized this approach to identify viral genes involved in modulation of interferon (IFN)-mediated cell signaling pathways. more

Publications Pathology

• Baicalein reduces β‐amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model

  Baicalein, a flavonoid isolated from the roots of Scutellaria baicalensis, is known to modulate γ‐aminobutyric acid (GABA) type A receptors. Given prior reports demonstrating benefits of GABAA modulation for Alzheimer's disease (AD) treatment, we wished to determine whether this agent might be ben more

• A TSPO ligand is protective in a mouse model of multiple sclerosis

  Abstract Local production of neurosteroids such as progesterone and allopregnanolone confers neuroprotection in central nervous system (CNS) inflammatory diseases. The mitochondrial translocator protein (TSPO) performs a rate‐limiting step in the conversion of cholesterol to pregnenolone and its more

• A Texture Based Pattern Recognition Approach to Distinguish Melanoma from Non-Melanoma Cells in Histopathological Tissue Microarray Sections

  by Elton Rexhepaj, Margrét Agnarsdóttir, Julia Bergman, Per-Henrik Edqvist, Michael Bergqvist, Mathias Uhlén, William M. Gallagher, Emma Lundberg, Fredrik Ponten Aims Immunohistochemistry is a routine practice in clinical cancer diagnostics and also an established technology for tissue-based rese more

Market studies Pathology

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

• Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020”. The report is an essential source of information and analysis on the global ovarian cancer therapeutics market. The report provi more

• Global Clinical Laboratory Testing Market Report: 2012 Edition

  Clinical laboratory testing market is one of the prime segments of healthcare industry. The market for clinical laboratory testing has seen significant growth in the recent years and it is expected that the market will continue to grow even further in near future. The growth of the market is mainly more

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