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News pathology

• China Medical Technologies and Leica Microsystems Announce Collaboration

  China Medical Technologies, Inc. (CMED) and Leica Biosystems, a division of Leica Microsystems, announced that they have established a sales, research and development collaboration to co-develop and market automated FISH kits to be used on the Leica BOND system. CMED will sell the Automated FISH Kit more

• Allon receives Michael J. Fox Foundation grant for Parkinson’s disease research

  Allon Therapeutics Inc. announced it has received a major grant from the Michael J. Fox Foundation (MJFF) for Parkinson’s Research to conduct pre-clinical research that will help determine the potential of the Company’s lead neuroprotective drug, davunetide, as a treatment for Parkinson’s disease (P more

• Allon’s Founding Scientist Illana Gozes awarded Olson Prize from Peptides journal

  Allon Therapeutics Inc. announced that Professor Illana Gozes, Allon’s founding scientist and the discoverer of Allon’s clinical-stage neuroprotective drug candidate davunetide, has been awarded the Olson Prize for her research insights into the behavioral effects of peptides by the journal Peptide more

White papers pathology

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in cell lines used for drug screening is highly important for anti-cancer drug discovery projects. Our purpose was to create a basic expression profile of ABC transporters in our mainly used lung cancer cell lines using the RealTime ready ABC Transporter Panel.The RealTime ready ABC-Transporter Panel comprises the 42 most important human ABC transporters in duplicate. The panel includes five controls for RNA quality and seven reference gene assays. The assays are supplied in a LightCycler® Instrument 480 Multiwell Plate 96 and contain target specific primers and a FAM-labeled Universal ProbLibrary hydrolysis probe that contains LNA more

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to neuroblastoma cells exposed to bortezomib, a proteasome inhibitor in clinical use. It has been shown previously that neuroblastoma cell lines are prone to undergo apoptosis when treated with bortezomib, but the precise molecular mechanism has not been revealed. In addition to this, peripheral neuropathy is the main side effect of chemotherapy that includes bortezomib more

• Evidence for a Cysteine Proteinase Involved in BSE Infection and/or Progression
  

  According to the "protein-only" hypothesis, the prion protein seemed to be - for more than a decade - the infectious agent of transmissible spongiform encephalopathies (TSEs) in different species. TSEs are neurodegenerative diseases reported e.g., for humans (Creutzfeld-Jakob disease, CJD), cattle (bovine spongiform encephalo­pathy, BSE), and sheep (scrapie). In contrast to the "protein-only" hypothesis, some researchers published data showing that retrovirus-like RNA transcripts, a viral structure, and viral particles might be involved in disease infection/progression of CJD. In addition, there is no final proof for the "protein-only" hypothesis and the infectivity of the prion protein. more

Publications pathology

• Subchronic inhalation toxicity of iron oxide (magnetite, Fe3O4) in rats: pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles

  ABSTRACT Wistar rats were nose‐only exposed to pigment‐sized iron oxide dust (Fe3O4, magnetite) in a subchronic 13‐week inhalation study according to the OECD testing guidelines TG#413 and GD#39. A 4 week pilot study with a 6 month post exposure period served as basis for validating the kinetic m more

• Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

  Abstract Autophagy plays a critical role in multiple pathological lesions of Alzheimer's disease (AD), such as the formation of amyloid plaques from amyloid‐β (Aβ) production and accumulation via dysregulating amyloid precursor protein turnover and enhancing the activity of β‐ and/or γ‐secretases more

• Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice

  Abstract Increasing evidence indicates that oxidative stress is an important mechanism underlying motor neuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). Mitochondrial DNA (mtDNA) is highly susceptible to oxidative damage and has little potential for repair, although mitochondrial more

Market studies pathology

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

• Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020”. The report is an essential source of information and analysis on the global ovarian cancer therapeutics market. The report provi more

• China Health Management Corp. - Strategic SWOT Analysis Review

  China Health Management Corp. (CHMC) engages in providing operations and management of hospitals in China. Its services include, hospital management consultation, commissioning hospital management, medical examination, medical imaging, medical functions examination, anesthesia, pathology, family war more

Websites pathology