Oligonucleotides

Companies Oligonucleotides

News Oligonucleotides

• Link Technologies Announces Partnership with American International Chemical

  Link Technologies Ltd has announced that it will partner with American International Chemical (AIC) to distribute Link-branded products in North America. AIC will offer a sub-set of Link’s specialist oligonucleotide reagents, focusing on the bulk market for oligonucleotide modifiers. The large-scale more

• Integrated DNA Technologies Acquires 1st BASE Oligonucleotide Business in Singapore

  Integrated DNA Technologies (IDT) has acquired the oligonucleotide business of 1st BASE Pte. Ltd.  IDT will now offer locally-manufactured oligos to researchers in Singapore and throughout the region from the company’s first synthesis facility in Asia.Dr. Joseph Walder, IDT’s founder and Chief Execu more

• Just the Two Of Us

  Nucleic acid technology has revolutionized the field of biomedicine, as it can be effectively utilized in the diagnosis, treatment, and prevention of genetic diseases. The efficacy of most oligonucleotide therapies is, however, limited as a result of the lability of oligonucleotides in biological fl more

White papers Oligonucleotides

• High Pure PCR Cleanup Micro Kit - Novel Flexibility for Nucleic Acid Purification
  

  Manual nucleic acid isolation with High Pure products is long approved by the scientific community. The product portfolio includes kits for isolation of genomic RNA and DNA, plasmid DNA as well as purification of reaction products. Key goal for all products is to offer optimal solutions suited for many different sample materials in order to reduce the number of different nucleic acid isolation kits necessary in modern molecular biology labs. more

• A Rapid, Sample-Safe, Evaporative Technique for Preparation of DNA and Oligonucleotide Samples
  

  When working with DNA and oligo samples great care needs to be taken at every stage to ensure that degradation does not occur, and the highly potent samples are not contaminated. Use of state of the art concentration systems can significantly speed up concentration rates, saving researchers time, and also eliminate potential sources of damage to samples more

• Experimental Workflow for Fast and Accurate Genotyping of Scrapie-resistant/sensitive Sheep
  

  Several scientific studies support the claim that natural scrapie is associated with polymorphisms at three codons within the sheep prion protein (PrP) gene. Genotyping of these codons (codon 136 [alanine, valine], 154 [arginine, histidine], and 171 [glutamine, arginine, histidine]) might enable breeding of sheep flocks with high resistance to scrapie. Fast and reliable high-throughput genotyping of sheep is a major issue, since scrapie is a serious problem in several European countries. To address this, an experimental procedure for DNA preparation and PCR-based detection of codon 136, 154, and 171 polymorphisms was established. more

Publications Oligonucleotides

• Primary blood neutrophils express a functional cell surface Toll‐like receptor 9

  Polymorphonuclear leukocytes (PMNs) represent one of the first lines of defense against pathogens. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen‐derived DNA. Here we show that freshly isolated human and mouse primary PMNs express TLR9 at the cell surface ex vi more

• TfReg: calculating DNA and RNA melting temperatures and opening profiles with mesoscopic models

  Summary: The mesoscopic statistical physics models, known generically as Peyrard–Bishop (PB) models, have found many applications for the study of oligonucleotide properties. Unfortunately, PB models have not reached a wider non-specialized audience for the lack of freely available software impleme more

• Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth [Medical Sciences]

  Aptamers, oligonucleotides able to avidly bind cellular targets, are emerging as promising therapeutic agents, analogous to monoclonal antibodies. We selected from a DNA library an aptamer specifically recognizing human epidermal growth factor receptor 2 (ErbB-2/HER2), a receptor tyrosine kinase, wh more

Websites Oligonucleotides