Liver Cells

News Liver Cells

• Giving transplanted cells a nanotech checkup

  Researchers at Johns Hopkins have devised a way to detect whether cells previously transplanted into a living animal are alive or dead, an innovation they say is likely to speed the development of cell replacement therapies for conditions such as liver failure and type 1 diabetes. The study used nan more

• Hepatitis C virus hijacks liver microRNA

  Viral diseases are still one of the biggest challenges to medical science. Thanks to thousands of years of co-evolution with humans, their ability to harness the biology of their human hosts to survive and thrive makes them very difficult to target with medical treatment.Scientists at the University more

• Medicyte gains significant support from BMWi - the German Federal Ministry of Economics and Technology

  Compounds that damage the human genome (i.e. genotoxic) are considered to carry the risk of causing cancer. For this reason, regulatory authorities require that all chemicals exposed to the consumer, such as drugs, cosmetics and (agro)chemicals should be tested for their potential to cause genotoxic more

White papers Liver Cells

• Increased Vitality of Primary Mouse Hepatocytes Isolated with Liberase TM Research Grade
  

  As drugs applied to organisms are metabolized via the liver, hepatocytes represent a useful and common study model. Primary hepatocytes are widely used to evaluate the toxic effects of drugs and xenobiotics. A variety of metabolic parameters have been described to analyze the functionality of hepatocytes. Via those parameters, the toxic effect of substances can easily be quantified. One drawback of primary hepatocyte culture is the short duration of survival and the high sensibility of the cells. Therefore, every step towards a more gentle method of isolating the cells increases cell number and vitality and thus improves the outcome of biomedical research applications more

• New Application for the LightCycler® 480 System: qPCR-based microRNA-Profiling
  

  Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies and therefore represent a promising new class of biomarkers. Quantitative PCR-based technologies are emerging as the gold standard for miRNA profiling. Here, a commercially available miRNA assay was used to measure and compare the expression levels of 154 miRNAs of seven lymph node samples using the LightCycler® 480 Instrument and a competitor real-time PCR system. We observed highly similar results for 134 miRNAs (87%) and some larger deviations (20 ­miRNAs/13%). In addition to large-scale miRNA profiling, it is also possible to use the LightCycler® 480 System in the assessment of miRNA expression in small sample sizes. We have conclusively demonstrated that miR-205 can be detected in a dose-dependent manner in a dilution series of 50, 10, 5, and 1 cell(s) of the KU19-19 cell line. more

Publications Liver Cells

• Mixtures of 3,4‐methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non‐c ...

  ABSTRACT Hepatic injury after 3,4‐methylenedioxymethamphetamine (MDMA; ecstasy) intoxications is highly unpredictable and does not seem to correlate with either dosage or frequency of use. The mechanisms involved include the drug metabolic bioactivation and the hyperthermic state of the liver tr more

• Frequent DNA methylation of MiR‐129‐2 and its potential clinical implication in hepatocellular carcinoma

  Hepatocellular carcinoma (HCC) is a highly malignant tumor with poor prognosis and high mortality due to a lack of effective medical treatment and apparent early stage symptoms. Understanding molecular mechanism of cancer development is crucial for HCC diagnosis, prognosis, and treatment. Recently more

• The Multifaceted Role of the Microenvironment in Liver Metastasis: Biology and Clinical Implications

  The liver is host to many metastatic cancers, particularly colorectal cancer, for which the last 2 decades have seen major advances in diagnosis and treatment. The liver is a vital organ, and the extent of its involvement with metastatic disease is a major determinant of survival. Metastatic cells a more

Market studies Liver Cells

• Pacific Pharmaceutical Co., Ltd. (016570) - Financial and Strategic SWOT Analysis Review

  Pacific Pharmaceutical Co., Ltd. (PPCL) is a publicly held pharmaceutical company. It is engaged in the development and manufacturing of pharmaceutical and medicinal products. The company’s product portfolio comprises of ethical medicine, such as plasters used in damaged bones, skins, sinews and fle more

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