Gene Variants

News Gene Variants

• 'Recruitment by genotype' for genetic research poses ethical challenges, study finds

  A potentially powerful strategy for studying the significance of human genetic variants is to recruit people identified by previous genetic research as having particular variants. But that strategy poses ethical challenges to informed consent, as well as potential risks to the people recruited, and more

• Population explosion has produced more rare gene variants than thought

  As the Earth's human population has skyrocketed since the rise of agriculture some 10,000 years ago - to 7 billion people from a few million - so, too, has the number of rare genetic variants. Since about 2,000 years ago (fewer than 100 generations), the human population has experienced an explosive more

• 'Speed gene' in modern racehorses originated from British mare 300 years ago, scientists say

  Scientists have traced the origin of the 'speed gene' in Thoroughbred racehorses back to a single British mare that lived in the United Kingdom around 300 years ago, according to findings published in Nature Communications.The origin of the 'speed gene' (C type myostatin gene variant) was revealed b more

Publications Gene Variants

• Microbial Variome Database: Point Mutations, Adaptive or Not, in Bacterial Core Genomes

  Analysis of genetic differences (gene presence/absence and nucleotide polymorphisms) among strains of a bacterial species is crucial to understanding molecular mechanisms of bacterial pathogenesis and selecting targets for novel antibacterial therapeutics. However, lack of genome-wide association s more

• Update on genetics of essential tremor

  Despite the research, few advances in the etiopathogenesis on essential tremor (ET) have been made to date. The high frequency of positive family history of ET and the observed high concordance rates in monozygotic compared with dizygotic twins support a major role of genetic factors in the develo more

• Association of Aggression With a Novel MicroRNA Binding Site Polymorphism in the Wolframin Gene

  Abstract Rare mutations in the WFS1 gene lead to Wolfram syndrome, a severe multisystem disorder with progressive neurodegeneration and diabetes mellitus causing life‐threatening complications and premature death. Only a few association studies using small clinical samples tested the possible e more

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