To use all functions of this page, please activate cookies in your browser.
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Mean corpuscular volume
In patients with anemia, it is the MCV measurement that allows classification as either a microcytic anemia (MCV below normal range) or macrocytic anemia (MCV above normal range).
If the MCV was determined by automated equipment, the result can be compared to RBC morphology on a peripheral blood smear. Any deviation would be indicative of either faulty equipment or technician error.
The normal range is typically 80-96 fL. In presence of hemolytic anaemia, presence of reticulocytes can increase MCV. In pernicious anemia (macrocytic), MCV can range up to 150 femtolitres. An elevated MCV is also associated with alcoholism (as are an elevated GGT and a ratio of AST:ALT of 2:1). Vitamin B12 deficiency has also been associated with macrocytic anemia (high MCV numbers). The most common causes of microcytic anemia are iron deficiency (due to inadequate dietary intake, gastrointestinal blood loss, or menstrual blood loss), thalassemia, or chronic disease. A low MCV number in a patient with a positive stool guaiac test (bloody stool) is highly suggestive of GI cancer. In iron deficiency anemia (microcytic anemia), it can be as low as 60 to 70 femtolitres. In cases of thalassemia, the MCV may be low even though the patient is not iron deficient.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mean_corpuscular_volume". A list of authors is available in Wikipedia.|