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Isocaudomers are pairs of restriction enzymes that have slightly different recognition sequences but upon cleavage generate identical termini. For example the enzymes Mbo I and BamH I are isocaudomers:

Mbo I 
BamH I

N represents any of the four nucleotides. Independently of which nucleotide is present when cleaving with MboI, after cleavage with either enzyme, all termini have the central tetranucleotide - GATC. This allows fragments generated with one enzyme to anneal with fragments generated with the other enzyme.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Isocaudomer". A list of authors is available in Wikipedia.
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