Diseases

News Diseases

• Presentation of the 2013 Eppendorf Award for Young European Investigators

  The British scientist Ben Lehner, Ph.D., ICREA Research Professor, EMBL-CRG Systems Biology Unit at the Centre de Regulació Genòmica, in Barcelona, Spain, has won the 2013 Eppendorf Young Investigator Award. Lehner, born 1978, receives the Eppendorf Award for his discoveries concerning the fundament more

• Link between faster 'biological' aging and risk of developing age-related diseases

  An international team of scientists led by the University of Leicester has found new evidence that links faster 'biological' ageing to the risk of developing several age-related diseases - including heart disease, multiple sclerosis and various cancers. The study involved scientists in 14 centres ac more

• Skin-deep communication: Messenger substance and signaling molecule influence the development of the skin’s immune cells

  A signalling molecule known as Axl has been discovered on immune cells of the epidermis. This recently published finding provides new insight into the development of important skin immune cells known as Langerhans cells. These cells fight off invading microorganisms and play a crucial role in our he more

White papers Diseases

• ORAC Assay Performed on the POLARstar Omega and PHERAstar FS microplate reader
  

  In all oxygen consuming cells, metabolism and oxidative stress generate several intermediates and byproducts that are collectively known as reactive oxygen species (ROS). ROS are necessary intermediates in the human body, but they are also involved in the aging process and in the development of many degenerative diseases, including cancer, heart disease, Alzheimer's and Parkinson's. Herein we describe the determination of the antioxidant capacity of different fruit juices using the ORAC assay; a standardized method that uses Trolox®, a water-soluble analogue of vitamin E, as a standard substance more

• miRNA Extraction and Profiling on FFPE Samples
  

  RNA silencing is a mechanism of gene regulation whereby small double-stranded RNAs (dsRNAs) of 21-18 nucleotides in length cause mRNA degradation, mRNA translation, or chromatin modification. In the past years, more than 500 novel genes have been identified in animals and plants encoding small transcripts that can form small dsRNA hairpin structures. From these hairpin precursors, small 22-nt RNAs - so called microRNAs (miRNA) - are excised by dsRNA-specific endonucleases. The miRNAs are then integrated in ribonucleoprotein particles (RNPs). Most miRNAs in animals act by binding to partially complementary regions of the 3' untranslated region of their target mRNA, thereby blocking translation. more

• Cytokine Quantification in Drug Development
  

  Immuno-PCR (IPCR) and ElectroChemiLuminescence (ECL) are technologies for improved performance of immunoassays. The specific advantages of the different technologies, using enzymatic or electrical signal amplification, allow for tailored assay design and address several specific challenges, such as maximum sensitivity up to 1 fg/ml target cytokine, simultaneous detection of multiple antigens, and high robustness against biological matrices more

Publications Diseases

• The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis

  Neuronal ceroid lipofuscinosis (NCL), commonly referred to as Batten disease, is a group of autosomal recessive neurodegenerative diseases of childhood characterized by seizures, blindness, motor and cognitive decline and premature death. Currently, there are over 400 known mutations in 14 differen more

• Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3

  Large intronic expansions of the triplet-repeat sequence (GAA.TTC) cause transcriptional repression of the Frataxin gene (FXN) leading to Friedreich's ataxia (FRDA). We previously found that GAA-triplet expansions stimulate heterochromatinization in vivo in transgenic mice. We report here using chr more

• Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells

  Small intestinal epithelial cells (sIECs) have a significant share in whole body metabolism as they perform enzymatic digestion and absorption of nutrients. Furthermore, the diet plays a key role in a number of complex diseases including obesity and diabetes. The impact of diet and altered genetic more

Market studies Diseases

• Uganda Pharmaceuticals and Healthcare Report Q2 2012

  BMI View: Uganda's pharmaceutical market is typical of developing markets: defined by an absence of a clear regulatory framework, a dependence upon drug imports and low healthcare expenditure per capita. Economic growth will aid the development of Uganda's pharmaceutical and healthcare sectors as af more

• HD Medical Group Pty Ltd. - Strategic SWOT Analysis Review

  HD Medical Group Limited (HD Medical) formerly HD Medical Group Limited is a medical device company. It is engaged in the development of proprietary and patented heart sound technology towards the diagnosis of cardiac diseases. The company design and develops devices that aid visual auscultation and more

• Miraculins Inc. - Strategic SWOT Analysis Review

  Miraculins Inc (Miraculins) is a research and development company engaged in the discovery and validation of cancer biomarkers, which enable the development of diagnostic tools and therapeutic products. The company focuses on biomarker discovery using its proprietary B.E.S.T Platform for the screeni more

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