Breast Cancer

News Breast Cancer

• Exercise-related changes in estrogen metabolism may lower breast cancer risk

  Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention. "Observational studies suggest physical activity lowers breast cancer risk, but there more

• Mammograms reveal response to common cancer drug
  

  Researchers at Karolinska Institutet have developed a method for assessing the effect of tamoxifen, a common drug to prevent the relapse of breast cancer. The key lies in monitoring changes in the proportion of dense tissue, which appears white on a mammogram, during treatment. Women who show a pron more

• Tomosynthesis increases breast cancer detection rate

  2D plus 3D breast imaging increases cancer detection rates by 11%, and could be particularly useful in detecting cancer in women with dense breasts, a new study suggests. Researchers at Yale University Smilow Cancer Hospital in New Haven, CT, reviewed the screening mammograms of 14,684 patients. For more

White papers Breast Cancer

• Mutation Scanning Using High Resolution Melting or dHPLC: a Performance Comparison Study
  

  High Resolution Melting (HRM) is a novel and promising screening technique used for mutation analysis and detection. Its application prevents the need to sequence all the exons of a gene when looking for novel mutations. The method is therefore time- and cost-effective for the analysis of large genes comprising many exons. In the research project described here, we compared HRM on the LightCycler® 480 System with denaturing high-performance liquid chromatography (dHPLC), a more conventional method for mutation scanning. A WAVE 4500 HT System has been used for many years in our accredited human genetic laboratory for screening human samples by dHPLC, to identify unknown mutations that can then be characterized in detail by sequence analysis more

• The xCELLigence System: Label-Free Measurement of Natural Killer Cell Cytotoxic Activity in Real Time
  

  Natural killer (NK) cells have been implicated in the recognition and annihilation of tumor cells. The assessment of the cytolytic activity of NK cells is important not only for monitoring of immunocompetence in cancer, infectious diseases, and autoimmune diseases, but also in determining the proteins which mediate the cytolytic effect. more

• Outstanding Microarray Experimental Results Using FuGENE® HD Transfection Reagent
  

  Transfection is a method for delivering nucleic acids, either DNA or RNA, into animal cells in vitro. In applications such as protein production, the main purpose is to produce protein; consequently any effects on endogenous gene expression are generally irrelevant, unless the changes relate directly to loss of the cell's ability to produce protein, i.e., cell death. In contrast, in applications where the biochemical pathways are of interest, changes within the cell can alter the interpretation of the data. Unintended up- or down-regulation of genes within transfected cells is termed an off-target effect. This may be caused by the reagent itself, the vector, or the process of transfection. Such effects, if not carefully evaluated, may lead to misinterpretation of the transfection results and to misleading conclusions. Critically important in transfection experiments is the selection of the appropriate control. more

Publications Breast Cancer

• Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas

  Androgen receptor (AR) expression by immunohistochemistry correlates with better prognosis and survival among breast cancer patients. We and others have shown that AR inhibits proliferation and induces apoptosis in breast cancer cells. However, the mechanism of AR's anti-tumor effect in breast canc more

• Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN‐λ and elevated secretion of Cxcl10

  Abstract The theory of cancer immunoediting refers to mechanisms by which the immune system can suppress or promote tumour progression. A major challenge for the development of novel cancer immunotherapies is to find ways to exploit the immune system's antitumour activity while concomitantly red more

• Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine

  Multidrug resistance (MDR) remains one of the major challenges for successful chemotherapy. Herein, we tried to develope a mitochondria targeted teniposide loaded self-assembled nanocarrier based on stearylamine (SA-TSN) to reverse MDR of breast cancer. SA-TSN was nanometer-sized spherical particles more

Market studies Breast Cancer

• IDL Biotech AB (IDL B) - Financial and Strategic SWOT Analysis Review

  IDL Biotech AB (IDL Biotech AB) is a Sweden based biotechnology company engaged in developing, manufacturing and marketing of in vitro diagnostics within the areas of oncology and bacteriology. The product pipeline of the company consists of TPS, TPAcyk, MonoTotal and UBC, which are cytokeratin tumo more

• Game Changers in Breast Cancer Therapies

  Breast cancer therapies are entering a new era as game-changers emerge for each of the major breast cancer patient populations. New market entrants must possess drug profiles and a savvy clinical development program to overcome such barriers to entry as a stringent regulatory environment and the inc more

• Novel Therapies in Oncology - Protein Kinase Inhibitors, Monoclonal Antibodies and Vaccines Therapeutic Classes Dominate Late-Stage Pipeline

  GBI Research, the leading business intelligence provider, has released its latest research, “Novel Therapies in Oncology - Protein Kinase Inhibitors, Monoclonal Antibodies and Vaccines Therapeutic Classes Dominate Late-Stage Pipeline” which provides insights into the global oncology pipeline. The re more

Websites Breast Cancer