Affymetrix

Companies Affymetrix

News Affymetrix

• Affymetrix and eBioscience Amend Definitive Merger Agreement

  Affymetrix, Inc.,  and eBioscience, Inc. announced they have amended their existing definitive agreement dated November 29, 2011 under which Affymetrix will acquire eBioscience. Under the terms of the amended agreement, Affymetrix will acquire eBioscience for $315 million in cash subject to usual ad more

• Draft sequence of Neandertal genome wins the 2010 AAAS Newcomb Cleveland Prize, supported by Affymetrix

  Composed of more than 4 billion nucleotides, a draft sequence of the Neandertal genome won the 2010 Newcomb Cleveland Prize of the American Association for the Advancement of Science (AAAS).The Association's oldest prize, now supported by Affymetrix, the Newcomb Cleveland Prize annually recognizes t more

• MDxHealth Outlines New Strategy

  MDxHealth, formerly known as OncoMethylome Sciences, announced further details regarding its revised business strategy. For the past several months, MDxHealth’s management has worked very closely with the Board of Directors to define a strategic path to accelerate growth and monetization of the Comp more

White papers Affymetrix

• Outstanding Microarray Experimental Results Using FuGENE® HD Transfection Reagent
  

  Transfection is a method for delivering nucleic acids, either DNA or RNA, into animal cells in vitro. In applications such as protein production, the main purpose is to produce protein; consequently any effects on endogenous gene expression are generally irrelevant, unless the changes relate directly to loss of the cell's ability to produce protein, i.e., cell death. In contrast, in applications where the biochemical pathways are of interest, changes within the cell can alter the interpretation of the data. Unintended up- or down-regulation of genes within transfected cells is termed an off-target effect. This may be caused by the reagent itself, the vector, or the process of transfection. Such effects, if not carefully evaluated, may lead to misinterpretation of the transfection results and to misleading conclusions. Critically important in transfection experiments is the selection of the appropriate control. more

• Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes
  

  To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million feature SNP arrays. A total of 201 somatic CNAs were found in the 86 AML genomes (mean, 2.34 CNAs per genome), with FAB-System M6 and M7 genomes containing the most changes (10-29 CNAs per genome). According to the authors' conclusions, the use of an unbiased high-resolution genomic screen identified many genes not previously implicated in AML that may be relevant for pathogenesis, along with many known oncogenes and tumor suppressor genes. Despite the ability of next-generation sequencing platforms to accurately identify amplifications, deletions, and translocations, a multiplatform approach (traditional cytogenetics, FISH, SNP array, array CGH, and targeted gene resequencing) will continue to be the most practical approach to studying AML genomes at most institut more

• RealTime ready qPCR Assay Design and Configuration Portal Content
  

  The gene and transcript annotational content of the RealTime ready Configurator offers a combined view of three of the main gene annotation authorities. The positional information of the lab-tested RealTime ready assays regarding transcript or exon coverage is presented in a graphical overview and tabular format. Additional content provides a convenient and browsable entry point for target gene selection for cataloged as well as new assays that are developed on demand more

Publications Affymetrix

• Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error

  Visual refractive errors (REs) are complex genetic traits with a largely unknown etiology. To date, genome-wide association studies (GWASs) of moderate size have identified several novel risk markers for RE, measured here as mean spherical equivalent (MSE). We performed a GWAS using a total of 7280 more

• Developmental transcriptional profiling reveals key insights into Triticeae reproductive development

  Summary Despite their importance, there remains a paucity of large scale gene expression‐based studies of reproductive development in the species belonging to the Triticeae. As a first step to address this deficiency, a gene expression atlas of triticale reproductive development was generated us more

• Differences in microRNA detection levels are technology and sequence dependent [ARTICLES]

  Identification and quantification of small RNAs are challenging because of their short length, high sequence similarities within microRNA (miRNA) families, and the existence of miRNA isoforms and O-methyl 3' modifications. In this study, the detection performance of three high-throughput commercial more

Market studies Affymetrix

• Global In Vitro Diagnostics Market 2011-2015

  TechNavio's analysts forecast the Global In Vitro Diagnostics market to grow at a CAGR of 6.55 percent over the period 2011-2015. One of the key factors contributing to this market growth is the increasing demand for biomarker-based tests worldwide. The Global In Vitro Diagnostics market has also be more

• EndoChoice Inc. - Product Pipeline Analysis

  EndoChoice Inc. - Product Pipeline Analysis Summary This report is a source for data, analysis and actionable intelligence on the EndoChoice Inc. portfolio of pipeline products. The report provides detailed analysis on each pipeline product with information on the indication, the development stage more

• Illumina, Inc. (ILMN) - Financial and Strategic SWOT Analysis Review

  Illumina, Inc. (ILMN) - Financial and Strategic SWOT Analysis Review Summary Illumina, Inc. (Illumina) is a molecular diagnostics company that principally focuses on the research and development of DNA and RNA Assays. It is involved in the development, manufacture and marketing of integrated syste more

Websites Affymetrix