Hepatitis C Virus Infection: Discovery of Unexpected Proviral Effect of Guanylate-Binding Protein 1 (GBP1)

02-Apr-2024 - A research team from the Paul-Ehrlich-Institut has gained important insights into the role of the human guanylate-binding protein 1 (GBP1) in hepatitis C virus infection. Their results show that GBP1 performs a previously unknown function, that of a proviral factor, during the HCV life cycle. ...

Deadly combination: new direct trigger for cell death discovered

Understanding the basic mechanisms that lead to cell death is essential for the development of therapies for cancer and other diseases

17-Jan-2022 - Scientists led by Professor Ana J. Garcia-Saez at the CECAD Cluster of Excellence for Aging Research at the University of Cologne have shown that apoptosis, the programmed cell death, involves a direct physical interplay between the two proteins BAX and DRP1. DRP1 can serve as a direct cell death ...

Trapping and watching motile cells

A new approach enables rapid characterization of living suspension cells in 4 dimensions

01-Apr-2015 - Optical imaging of highly motile cells or cells in suspension, such as bacterial systems, yeast cells, and immune cells, is a challenging task, in many cases it is just not possible. The human immunodeficiency virus (HIV), for example, can spread very efficiently from an infected T cell to an ...