Kinase Inhibitors

Companies Kinase Inhibitors

Biaffin GmbH & Co KG, Germany

Biaffin is specialising in biomolecular interaction analysis and has acquired long experience and expert knowledge in the application of biosensors based on surface plasmon resonance (SPR). Well-equipped with a number of different Biacore SPR biosensors Biaffin is able to start new projects for cust more

CBT Pharmaceuticals Inc, USA

CBT Pharmaceuticals is a biopharmaceutical company focused on developing innovative oncology therapeutics harnessing the immune system and targeting specific molecular pathways to tame cancer.The company was founded in 2016 with headquarters in California with international partners. Our pipeline is more

HepaRegeniX GmbH, Germany

HepaRegeniX, founded in 2015, specializes in the discovery and development of small molecule kinase inhibitors. The management team, led by Dr. Wolfgang Albrecht, and scientific advisors have over 20 years of experience in the pharmaceutical industry with a proven track record in drug development an more

News Kinase Inhibitors

• Pharmaceutical research: when active substance and target protein “embrace” each other
  

  Scientists at Goethe University Frankfurt, together with colleagues from Darmstadt, Heidelberg, Oxford and Dundee (UK), have investigated how the fit of potent inhibitors to their binding sites can be optimised so that they engage longer with their target proteins. Long target residency has been ass more

• Drug suppresses spread of breast cancer
  

  Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores C more

• Nanoshells could deliver more chemo with fewer side effects
  

  Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside cancer cells in laboratory cultures. The study employed gold nanoshells to more

Publications Kinase Inhibitors

• Computer-aided drug design and virtual screening of targeted combinatorial libraries of mixed-ligand transition metal complexes of 2-butanone thiosemicarbazone

  Publication date: August 2018 Source:Computational Biology and Chemistry, Volume 75 Author(s): Tahmeena Khan, Rumana Ahmad, Iqbal Azad, Saman Raza, Seema Joshi, Abdul Rahman Khan The present paper deals with in silico evaluation of 32 virtually designed transition metal complexes o more

• Viruses, Vol. 10, Pages 306: 1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features

  Viruses, Vol. 10, Pages 306: 1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features Viruses doi: 10.3390/v10060306 Authors: Sarah Moeschler Samira Locher Gert Zimmer Cellular kinases are crucial for the transcr more

• In silico-in vitro discovery of untargeted kinase–inhibitor interactions from kinase-targeted therapies: A case study on the cancer MAPK signaling pathway

  Publication date: August 2018 Source:Computational Biology and Chemistry, Volume 75 Author(s): Li Meng, Zhijun Huang Protein kinase inhibitors have been widely used as therapeutic agents to treat a variety of diseases, but many of them may cause off-target effects by unexpectedly targeting more