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Vector (biology)



In epidemiology, a vector is an organism that does not cause disease itself but which spreads infection by conveying pathogens from one host to another.

A classic example is the anopheles mosquito which acts as a vector for the disease malaria by transmitting the malarial parasite plasmodium to humans. In this case plasmodium is harmless to the mosquito (its intermediate host) but causes the disease malaria in humans (its definitive host).

In molecular biology and genetic engineering a vector is a vehicle for transferring genetic material into a cell.

A viral vector is a virus which has been modified to transduct specific genetic material into a cell, e.g. for gene therapy.

A plasmid vector is made by splicing a DNA construct into a plasmid. Various techniques are then used to transfect the plasmid into the cell.

Additional recommended knowledge

Contents

Epidemiology

There are two types of vector that convey infectious organisms to a host: mechanical and biological. Microbes do not multiply within mechanical vectors - mechanical vectors only physically transport microbes from host to host. In contrast, microbes must propagate within a biological vector before the biological vector can transmit the microbes.

Cell transformation and gene therapy

DNA

  • SV40 (Simian virus 40)
  • Plasmid
  • Yeast artificial chromosome (Chromosome walking, Positional cloning)
  • Bacterial artificial chromosome (Shotgun sequencing)

See also

  • Vector DNA

References

  • "Malaria Glossary", Centers for Disease Control and Prevention. Retrieved on 2007-05-30. 

External links

  • Gene Therapy Net
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Vector_(biology)". A list of authors is available in Wikipedia.
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