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Fumonisin B1



Fumonisin B1
Other names Macrofusine
Identifiers
CAS number 116355-83-0
Properties
Molecular formula C34H59NO15
Molar mass 721.8
Appearance White to off-white powder
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Fumonisine B1 is an inhibitor of ceramide synthase.

Additional recommended knowledge

Fumonisin B1 is the most prevalent member of a family of toxins produced by several species of Fusarium moulds which occur mainly in maize. Fumonisin B1 contamination of maize has been reported worldwide at mg/kg levels. Human exposure occurs at levels of micrograms to milligrams per day and is greatest in regions where maize products are the dietary staple.

Fumonisin B1 is hepatotoxic and nephrotoxic in all animal species tested. The earliest histological change to appear in either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity of fumonisin is low, it is the known cause of two diseases which occur in domestic animals with rapid onset: equine leukoencephalomalacia and porcine pulmonary oedema syndrome. Both of these diseases involve disturbed sphingolipid metabolism and cardiovascular dysfunction.

References

    • http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/212211.htm&word=leukoencephalomalacia
     
    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fumonisin_B1". A list of authors is available in Wikipedia.
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