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RNA Interference

The technique regularly makes the science headlines, and drugs it is based on have reached the clinical development stage – RNA interference is on everyone’s lips, thanks to enabling a comparatively straightforward technique of silencing genes. The market volume of RNAi products and services is predicted to reach four thousand million US dollars by 2017, with siRNA synthesis seen as having the greatest growth potential.

Companies RNA Interference

SIRION BIOTECH GmbH, Germany

SIRION Biotech is Europe's leading commercial supplier of viral vectors used for genetic cell modelling, gene target validation and gene therapy- and vaccination studies. Since its foundation in 2007, SIRION’s mission has been to change the paradigm for viral vector supplies. It has the ability to more

Merck Chemicals GmbH, Germany

Merck Millipore is the Life Science division of Merck KGaA of Germany and offers a broad range of innovative, performance products, services and business relationships that enable our customers’ success in research, development and production of biotech and pharmaceutical drug therapies. Through ded more

Products RNA Interference

Speed up compound & target research with novel and reliable in vitro cell models

RNAiONE - Identification of optimal shRNA sequences for knockdown cell systems, for target validation and for screening applications more

News RNA Interference

  • How a molecular Superman protects the genome from damage

    How many times have we seen Superman swoop down from the heavens and rescue a would-be victim from a rapidly oncoming train? It's a familiar scenario, played out hundreds of times in the movies. But the dramatic scene is reenacted in real life every time a cell divides. In order for division to occu more

  • Scientists discover new, noncommittal mechanism of drug resistance

    Microorganisms like bacteria and fungi can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. These permanent mutations were once thought to be the only way for drug-resistant strains to evolve. Now a new study has shown that microorganisms can use a tem more

  • PBL awared further US patents on short RNAi molecules

    Plant Bioscience Limited (PBL) announced that the United States Patent and Trademark Office (USPTO) has issued US Patent No. 8,759,102 and US Patent No. 8,779,236 with fundamental claims directed to RNAi in cells and organisms to effect gene silencing. These two new patents granted add to the streng more

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White papers RNA Interference

  • qPCR Validation of Candidates for Modulators of the MAPkinase Signaling Pathway

    With the completion of the human genome sequence, the detailed understanding of gene functions by analyzing the structure, biological activities, and dynamics of the encoded proteins has become the next challenge. The technology of RNA interference (RNAi), which allows the silencing of genes by introduction of small interfering RNA (siRNA), is recognized as an extremely powerful tool for systematic high-throughput functional genomic screening. more

  • HelpCorner - Gene Silencing

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  • Dynamics of Kinases Involved in Cell Growth Using the xCELLigence System

    Studies investigating endogenous cellular regulatory mechanisms have substantially pushed the application of high-throughput screens. RNA interference has developed into an extremely powerful tool for mediating the loss-of-function of specific mRNA molecules and preventing their translation into proteins. Numerous studies have helped to uncover novel gene functions in many biological processes, but most have used single endpoint analysis as readout for the respective phenotypes to characterize the outcome of a cascade of regulatory mechanisms. The xCELLigence System offers a new way to analyze the effect of gene knock downs on living cells, as the system provides continuous, quantitative information about the electrical impedance at the bottom surface of microtiter plates. Thus, any change in cell number, cell morphology or cell attachment can be detected in real-time. more

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Publications RNA Interference

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Market studies RNA Interference

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Definition

RNA interference

RNA interference trims double stranded RNA, to form small interfering RNA or microRNA . These processed RNAs are incorporated into the RNA-induced silencing complex (RISC), which targets messenger RNA to prevent translation . RNA interferen ... more

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