RNA Interference

Companies RNA Interference

Merck Chemicals GmbH, Germany

Merck Millipore is the Life Science division of Merck KGaA of Germany and offers a broad range of innovative, performance products, services and business relationships that enable our customers’ success in research, development and production of biotech and pharmaceutical drug therapies. Through ded more

SIRION BIOTECH GmbH, Germany

SIRION BIOTECH is a technology leader in the field of functional gene analysis and cell models for basic research, drug and compound development. The company serves leading European and Japanese Drug and Biotech companies as a provider of latest technologies for them to advance identification of nov more

Santa Cruz Biotechnology, Inc., USA

Santa Cruz Biotechnology, Inc. is focused on the ongoing development of research antibodies. It is our goal to continue to offer the broadest range of research reagents in the field. We provide superior, innovative primary antibodies and support products. We are the leading worldwide source of prod more

News RNA Interference

• PBL awarded two US patents on RNAi

  Plant Bioscience Limited (PBL) announced that the United States Patent and Trademark Office (USPTO) has issued out US Patent No. 8,258,285 with fundamental claims directed to compositions to effect gene silencing and US Patent No. 8,263,569 with fundamental claims directed to methods of inducing gen more

• Alnylam and PBL Sign Licence Agreement for Baulcombe & Hamilton RNAi patent

  Alnylam Pharmaceuticals, Inc. and Plant Bioscience Limited (PBL) announced  that they have entered into a licensing agreement.  PBL has granted Alnylam a world-wide, non-exclusive license to the Baulcombe patent (U.S. Patent No. 8,097,710) for use in the field of human therapeutics.  Financial terms more

• Heparin-like compounds inhibit breast cancer metastasis to bone

  Researchers from VTT Technical Research Centre of Finland have in collaboration with the University of Turku, Indiana University and two Finnish companies, Biotie Therapies Corp. and Pharmatest Services Ltd, discovered a novel mechanism regulating the development of breast cancer bone metastases and more

White papers RNA Interference

• Dynamics of Kinases Involved in Cell Growth Using the xCELLigence System
  

  Studies investigating endogenous cellular regulatory mechanisms have substantially pushed the application of high-throughput screens. RNA interference has developed into an extremely powerful tool for mediating the loss-of-function of specific mRNA molecules and preventing their translation into proteins. Numerous studies have helped to uncover novel gene functions in many biological processes, but most have used single endpoint analysis as readout for the respective phenotypes to characterize the outcome of a cascade of regulatory mechanisms. The xCELLigence System offers a new way to analyze the effect of gene knock downs on living cells, as the system provides continuous, quantitative information about the electrical impedance at the bottom surface of microtiter plates. Thus, any change in cell number, cell morphology or cell attachment can be detected in real-time. more

• qPCR Validation of Candidates for Modulators of the MAPkinase Signaling Pathway
  

  With the completion of the human genome sequence, the detailed understanding of gene functions by analyzing the structure, biological activities, and dynamics of the encoded proteins has become the next challenge. The technology of RNA interference (RNAi), which allows the silencing of genes by introduction of small interfering RNA (siRNA), is recognized as an extremely powerful tool for systematic high-throughput functional genomic screening. more

• High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System
  

  Although congenital heart malformations are the most common birth defects in humans, the underlying patho­mechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, NKX2-5) have been identified. However, most heart malformations display variable expressivity and pene­trance, which indicates a multifactorial and multigenic basis. This suggests that the regulatory context of transcription factors plays an important role in the manifestation of the defects. In order to better understand the molecular pathways in cardiogenesis and disease we studied the global genetic network that is deregulated in malformed hearts more

Publications RNA Interference

• Learning gene network structure from time laps cell imaging in RNAi Knock downs

  Motivation: As RNA interference is becoming a standard method for targeted gene perturbation, computational approaches to reverse engineer parts of biological networks based on measurable effects of RNAi become increasingly relevant. The vast majority of these methods use gene expression data, but more

• Multifunctional Nanoparticles Improve Therapeutic Effect for Breast Cancer by Simultaneously Antagonizing Multiple Mechanisms of Multidrug Resistance

  For efficient reversal of multidrug resistance (MDR) in chemotherapy for breast cancer, multifunctional self-assembled nanoparticles (MSN) based on a new amphiphilic copolymer consisting of bioreducible poly[bis(2-hydroxylethyl)-disulfide-diacrylate-β-tetraethylenepentamine] and polycaprolactone (PB more

• Juvenile Hormone and Insulin Regulate Trehalose Homeostasis in the Red Flour Beetle, Tribolium castaneum

  by Jingjing Xu, Zhentao Sheng, Subba Reddy Palli Insulin/IGF-1 signaling (IIS) has been well studied for its role in the control of life span extension and resistance to a variety of stresses. The Drosophila melanogaster insulin-like receptor (InR) mutant showed extended life span due to reduced more

Market studies RNA Interference

• Genesis Research and Development Corporation Limited (GEN) - Financial and Strategic SWOT Analysis Review

  Genesis Research and Development Corporation Ltd. (Genesis) is a publicly held NewZealand-based biotechnology company. The company is principally engaged in the development of therapeutics for the treatment of cancer and diseases of the immune system. It is completely focused on the development of t more

• Genesis Research and Development Corporation Ltd. (GEN) - Financial and Strategic SWOT Analysis Review

  Genesis Research and Development Corporation Ltd. (Genesis) is a publicly held NewZealand-based biotechnology company. The company is principally engaged in the development of therapeutics for the treatment of cancer and diseases of the immune system. It is completely focused on the development of t more

• RXi Pharmaceuticals Corporation (RXII) - Financial and Strategic SWOT Analysis Review

  RXi Pharmaceuticals Corporation (RXi) is a discovery-stage bio-pharmaceutical company which is engaged in discovering, developing and commercializing novel therapeutics based on RNA interference (RNAi) to treat human diseases. By using its RNAi platform that includes RNAi compounds and delivery meth more

Websites RNA Interference