Topic pain

News pain

• Convergence Pharmaceuticals Announces Start of Phase II Study for CNV1014802 for Trigeminal Neuralgia

  Convergence Pharmaceuticals Limited announced that the Phase II proof of concept study for CNV1014802 for the treatment of pain associated with trigeminal neuralgia (TN) has started. CNV1014802 is novel small molecule, state-dependent sodium channel blocker that exhibits potency and selectivity agai more

• Scripps research scientists identify protein that sends 'painful touch' signals

  In two landmark papers in the journal Nature, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch."Scientists have known that sensory nerves in our skin detect pressure, pain, heat, cold, and other stimuli using specialized "io more

• Rapid Rise in Opioid Abuse is Among the Challenges Faced by Pain Therapy Drug Developers

  According to a new Espicom report, Evolution in the Pain Therapy Market: Nociceptive and Neuropathic Drug Development, despite a plethora of medications, the pain market remains an area of high unmet need as current therapies are often less than effective and/or have undesirable side effects.  Among more

Publications pain

• Involvement of the L‐arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N‐palmitoyl‐ethanolamine in rats

  Abstract N‐palmitoyl‐ethanolamine (PEA) is an endogenous substance that was first identified in lipid tissue extracts. It has been classified as a CB2 receptor agonist. Exogenous PEA has the potential to become a valid treatment for neuropathic and inflammatory pain. In spite of the well‐demonstr more

• Antinociceptive and anti‐exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice

  Abstract Preclinical studies have demonstrated antinociceptive synergism between dexketoprofen (DEX) and tramadol (TRM) in acute animal models of nociception. The aim of the present study was to investigate the type of interaction between DEX and TRM in a chronic musculoskeletal pain model in mic more

• Brain‐derived neurotrophic factor modulates N‐methyl‐D‐aspartate receptor activation in a rat model of cancer‐induced bone pain

  Abstract Brain‐derived neurotrophic factor (BDNF) released within the spinal cord induces phosphorylation of N‐methyl‐D‐aspartate (NMDA) receptors on the spinal cord neurons. This process is necessary for maintaining pain hypersensitivity after nerve injury. However, little is known about the rol more

Market studies pain

• Dental Pain Global Clinical Trials Review, H1, 2012

  Introduction GlobalData's clinical trial report, “Dental Pain Global Clinical Trials Review, H1, 2012" provides data on the Dental Pain clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Dental Pain. It includes an overview of the trial n more

• Acute Pain – Pipeline Review, H1 2012

  Introduction Global Markets Direct’s, 'Acute Pain - Pipeline Review, H1 2012', provides an overview of the Acute Pain therapeutic pipeline. This report provides information on the therapeutic development for Acute Pain, complete with latest updates, and special features on late-stage and discontin more

• Musculoskeletal Pain Global Clinical Trials Review, H1, 2012

  Introduction GlobalData's clinical trial report, “Musculoskeletal Pain Global Clinical Trials Review, H1, 2012" provides data on the Musculoskeletal Pain clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Musculoskeletal Pain. It includes more

Websites pain