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Sanofi and Regeneron Announce Start of Phase 3 Study of Dupilumab in Patients with Atopic Dermatitis

21-10-2014

Sanofi and Regeneron Pharmaceuticals, Inc. announced that the first patients have been dosed in a Phase 3 clinical study of dupilumab, an investigational therapy that blocks IL-4 and IL-13 signaling, in adults with moderate-to-severe atopic dermatitis (AD) that is not adequately controlled with ...

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Earlier unknown molecular-level mechanism may contribute to the growth rate of breast cancer

21-10-2014

Researchers at VTT Technical Research Centre of Finland, the University of Turku and the University of Oslo have discovered a previously unknown molecular-level mechanism that may partly explain the increased growth of cancer cells. The study, published in the British Journal of Cancer, showed ...

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New perspectives for development of an RSV vaccine

21-10-2014

Respiratory Syncytial Virus causes severe respiratory tract infections and worldwide claims the lives of 160,000 children each year. Scientists at VIB and Ghent University have succeeded in developing a promising vaccination strategy to counteract this common virus infection. Xavier Saelens ...

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Start signal for transcription of stressed genes identified

20-10-2014

What happens when a cell is stressed? In their latest study, Christian Seiserand his team at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna addressed this question. They identified which genes of the cell are activated under stress, showed ...

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Adenosine can melt "love handles"

20-10-2014

The number of overweight persons is greatly increasing worldwide - and as a result is the risk of suffering a heart attack, stroke, diabetes or Alzheimer's disease. For this reason, many people dream of an efficient method for losing weight. An international team of researchers led by Professor ...

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Researchers Identify “Naïve-Like” Human Stem Cells

20-10-2014

In their search for the earliest possible stage of development of human embryonic stem cells (hESCs) that still have the potential to develop into any types of body cells and tissue, researchers from the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, and the University of ...

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Sugared soda consumption, cell aging associated in new study

UCSF scientists find shorter telomeres in immune cells of soda drinkers

20-10-2014

Sugar-sweetened soda consumption might promote disease independently from its role in obesity, according to UC San Francisco researchers who found in a new study that drinking sugary drinks was associated with cell aging. The study revealed that telomeres — the protective units of DNA that cap ...

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How a molecular Superman protects the genome from damage

Scientists find a new role for RNAi protein Dicer in preventing collisions during DNA replication

20-10-2014

How many times have we seen Superman swoop down from the heavens and rescue a would-be victim from a rapidly oncoming train? It's a familiar scenario, played out hundreds of times in the movies. But the dramatic scene is reenacted in real life every time a cell divides. In order for division to ...

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Immune cells in the liver drive fatty liver disease and liver cancer

17-10-2014

Immune cells that migrate to the liver and interact there with liver tissue cells get activated by metabolic stress (e.g. through lipids of a high fat diet) and drive the development of fatty liver disease, non-alcoholic steatohepatitis and liver cancer. Scientists from the Helmholtz Zentrum ...

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Sucessful Spin-Out of ImevaX GmbH from the Technische Universität München

17-10-2014

ImevaX GmbH commenced its research and development activities in their own premises in Munich on Sep. 1st, 2014. With this step, ImevaX realized a successful spin-out from the Technische Universität München (TUM). A key factor for the success of the founder Professor Markus Gerhard and his team, ...

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