Lung Cancer

News Lung Cancer

• Researchers pinpoint how trees play role in smog production

  After years of scientific uncertainty and speculation, researchers at the University of North Carolina at Chapel Hill show exactly how trees help create one of society's predominant environmental and health concerns: air pollution. It has long been known that trees produce and emit isoprene, an abun more

• Asbestos exposure, asbestosis, and smoking combined greatly increase lung cancer risk

  The chances of developing lung cancer associated with asbestos exposure, asbestosis and smoking are dramatically increased when these three risk factors are combined, and quitting smoking significantly reduces the risk of developing lung cancer after long-term asbestos exposure, according to a new s more

• The adult generations of today are less healthy than their counterparts of previous generations

  Despite their greater life expectancy, the adults of today are less "metabolically" healthy than their counterparts of previous generations. That's the conclusion of a large cohort study from the Netherlands which compared generational shifts in a range of well established metabolic risk factors for more

White papers Lung Cancer

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in cell lines used for drug screening is highly important for anti-cancer drug discovery projects. Our purpose was to create a basic expression profile of ABC transporters in our mainly used lung cancer cell lines using the RealTime ready ABC Transporter Panel.The RealTime ready ABC-Transporter Panel comprises the 42 most important human ABC transporters in duplicate. The panel includes five controls for RNA quality and seven reference gene assays. The assays are supplied in a LightCycler® Instrument 480 Multiwell Plate 96 and contain target specific primers and a FAM-labeled Universal ProbLibrary hydrolysis probe that contains LNA more

• Aphidicolin-Mediated Replication Stress Induces Submicroscopic Tumor-Like Deletions in FHIT/FRA3B
  

  Common fragile sites (CFSs) are loci that are particularly susceptible to forming gaps and breaks on metaphase chromosomes after partial inhibition of DNA synthesis, for example induced by aphidicolin (APH). FRA3B, a fragile site lying within the FHIT tumor suppressor gene, is a site of frequent heterozygous and homozygous deletions in cancer cells and precancerous lesions. Most FHIT and other CFS-associated gene rearrangements in tumors are deletions of hundreds of kilobases often resulting in the inactivation of associated genes. However, there has been no direct evidence showing that CFS instability or replication stress can induce submicroscopic deletions like the ones found in cancer cells. Durkin et al. produced FHIT/FRA3B deletions similar to those in tumor cells by inducing replication stress in human-mouse chromosome 3 somatic hybrid cells with APH. more

Publications Lung Cancer

• New dilemmas in small-cell lung cancer TNM clinical staging

  Zarogoulidis K, Latsios D, Porpodis K, Zarogoulidis P, Darwiche K, Antoniou N, Hohenforst-Schmidt W, Eleftheriadou E, Boutsikou E, Kontakiotis T more

• Functional genomics lead to new therapies in follicular lymphoma

  Recent technological advances allow analysis of genomic changes in cancer in unprecedented detail. The next challenge is to prioritize the multitude of genetic aberrations found and identify therapeutic opportunities. We recently completed a study that illustrates the use of unbiased genetic scree more

• RXR{alpha} Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

  The transcription factor NRF2 (NFE2L2) is a pivotal activator of genes encoding cytoprotective and detoxifying enzymes that limit the action of cytotoxic therapies in cancer. NRF2 acts by binding antioxidant response elements (ARE) in its target genes, but there is relatively limited knowledge about more

Market studies Lung Cancer

• Non-Small Cell Lung Cancer – Pipeline Review, H1 2012

  Introduction Global Markets Direct’s, 'Non-Small Cell Lung Cancer - Pipeline Review, H1 2012', provides an overview of the Non-Small Cell Lung Cancer therapeutic pipeline. This report provides information on the therapeutic development for Non-Small Cell Lung Cancer, complete with latest updates, more

• Small-Cell Lung Cancer Global Clinical Trials Review, H1, 2012

  Introduction GlobalData's clinical trial report, “Small-Cell Lung Cancer Global Clinical Trials Review, H1, 2012" provides data on the Small-Cell Lung Cancer/Impaired Glucose Toleranceclinical trial scenario. This report provides elemental information and data relating to the clinical trials on Sm more

• Non-Small Cell Lung Cancer – Pipeline Review, H2 2012

  Introduction Global Markets Direct’s, 'Non-Small Cell Lung Cancer - Pipeline Review, Global Markets Direct’s, 'Non-Small Cell Lung Cancer - Pipeline Review, H2 2012', provides an overview of the indication’s therapeutic pipeline. This report provides information on the therapeutic development for more

Websites Lung Cancer