Ion Exchangers

Products Ion Exchangers

Protein Purification as easy as filtration

The Vivapure Ion Exchange spin columns are centrifugal devices, incorporating Sartobind Membrane Adsorber technology as their chromatography matrix more

The "smart" anion exchange chromatography resin: EshmunoTM Q

Thanks to the proven tentacle structure combined with hydrophilic polyvinyl ether base matrix superior productivity and maximum performance in downstream processing are possible. Eshmuno(TM) Q offers outstanding results in typical anion exchange applications more

News Ion Exchangers

• Tosoh Bioscience celebrates its 20th Anniversary
  

  20 years ago, on July 20, 1989, TosoHaas opened the doors to the Biopharmaceutical industry. Starting out with a team of five employees, TosoHaas, over time, developed into a profitable business with constant growth. In the start TosoHaas focused on promoting the nowadays well known TSK-GEL SW and more

• Pall Expands Line of Proteomics Technologies for Full Range of Drug Discovery and Development Solutions

  Pall Corporation launches a comprehensive line of chromatography sorbents at PepTalk 2005. These advanced industry-proven sorbents from Pall greatly simplify protein separation and purification for biotechnology drug discovery, development and production. The integration of this broad range of chrom more

White papers Ion Exchangers

• Increased productivity for downstream processing of biotherapeutics
  

  Polymer-based chromatographic resins featuring high mechanical and chemical stability and high protein binding capacities can help to increase the throughput and robustness of biopharmaceutical manufacturing processes. Advances in genetic engineering and cell culture technology have raised upstream productivity in the production of recombinant proteins. Increased titres of up to 10 g/l stress the need for highly efficient and robust downstream processes (DSP). Most industrial bioprocess development groups apply generic DSP platforms that are designed to purify various candidates of the same class of proteins applying the same process design. Besides various filtration and virus inactivation steps, they usually involve two or three chromatographic unit operations with orthogonal separation modes. The use of high capacity chromatographic resins can help to overcome the DSP bottleneck by increasing process throughput and robustness more

• Characterizing Biotherapeutics with HPLC
  

  As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. The introduction of the first so-called biosimilars in Europe further increased the demand for highly efficient analysis methods. The continuous development of new stationary phases for the common modes of biochromatography, such as size exclusion, ion exchange and hydrophilic interaction chromatography support biochemists in increasing lab productivity and establishing high-throughput HPLC analysis not only for small molecules but also for large biopolymers more

• From Sephadex to GE Healthcare
  

  The success of chromatography as a technique for separating biomolecules is inevitably linked to the introduction of the gel filtration medium Sephadex(TM) by Pharmacia AB in 1959 more

Publications Ion Exchangers

• Ultradepletion of Human Plasma using Chicken Antibodies: A Proof of Concept Study

  Human plasma arguably represents the most comprehensive version of the human proteome. Despite its immense theoretical discovery potential, plasma has many high and medium abundance proteins that mask low abundance protein disease biomarkers of relevance, making the discovery of novel diagnostic mar more

• Separation, antitumor activities, and encapsulation of polypeptide from Chlorella pyrenoidosa

  Chlorella pyrenoidosa is a unicellular green algae and has been a popular foodstuff worldwide. However, no reports on the antitumor peptides from such a microalgae are available in the literature. In this study, using low‐temperature high‐pressure extraction, enzymatic hydrolysis, ion exchange, an more

• Surface Engineering of Ultrafine Cellulose Nanofibrils toward Polymer Nanocomposite Materials

  Surface grafting of crystalline and ultrafine cellulose nanofibrils with poly(ethylene glycol) (PEG) chains via ionic bonds was achieved by a simple ion-exchange treatment. The PEG-grafted cellulose nanofibrils exhibited nanodispersibility in organic solvents such as chloroform, toluene, and tetrahy more

Websites Ion Exchangers