Internal Medicine

Products Internal Medicine

Setting New Standards in Steroid Hormone Analysis

SteroIDQ® Kit allows for the simultaneous analysis of a panel of 16 steroid hormones using tandem mass spectrometry from a single blood sample more

News Internal Medicine

• Demand for hybrid solutions to spur European interventional radiology and cardiology markets, finds Frost & Sullivan

  The European market for interventional radiology and cardiology is heading towards maturity, especially in Western Europe. Although the economic slowdown and fewer orders had a negative impact on revenues in 2012, it is expected that expanding applications of interventional systems and the popularis more

• Study suggests early exposure to antibiotics may impact development, obesity

  Researchers at NYU School of Medicine have made a discovery that could have widespread clinical implications, potentially affecting everything from nutrient metabolism to obesity in children.Since the 1950's, low dose antibiotics have been widely used as growth promoters in the agricultural industry more

• Sysmex and Roche renew successful alliance in the hematology business

  Sysmex Corporation and Roche announced the signing of a restated 10 years distribution, sales and services agreement (“DSS Agreement”). Under the agreement, Roche will continue to distribute the Sysmex hematology products, including instruments, reagents and data management solutions in selected cou more

White papers Internal Medicine

• Cytokine Quantification in Drug Development
  

  Immuno-PCR (IPCR) and ElectroChemiLuminescence (ECL) are technologies for improved performance of immunoassays. The specific advantages of the different technologies, using enzymatic or electrical signal amplification, allow for tailored assay design and address several specific challenges, such as maximum sensitivity up to 1 fg/ml target cytokine, simultaneous detection of multiple antigens, and high robustness against biological matrices more

• To Probe or Not to Probe
  

  In our efforts to measure the expression levels of the thyroid hormone receptor ß2 in small areas of mouse brain, we encountered primer-dimer prob­lems when using SYBR Green I assays. With the Universal ProbeLibrary and the LightCycler® 2.0 Instrument we were able to solve the primer-dimer problem, increase PCR efficiency, and continue our investigations. more

• Real-Time Analysis of LNCaP Cell Growth in Different Media
  

  Our results suggest that the influence of androgen receptor-stimulating or -blocking substances strongly depends upon the composition of the growth medium. The use of hormone-depleted FBS in combination with phenol red-free medium is strongly recommended for monitoring stimulator effects, whereas inhibitory effects may be more readily analyzed in medium containing normal FBS. Because the mutated androgen receptor in LNCaP can also be stimulated by estrogens, progestogens, and several antiandrogens, we suggest that the stimulatory effect of normal FBS compared with hormone-reduced FBS may be explained by differences in estradiol levels (192 pg/ml in normal FBS compared with <12 pg/ml in hormone-reduced FBS) rather than by differences in progesterone levels (0.29 ng/ml in normal FBS compared with 0.13 ng/ml in hormone-reduced FBS) or testosterone levels (0.08 ng/ml in normal FBS compared with 0.03 ng/ml in hormone-reduced FBS). Our results show that the optimal time point for monitoring inhibitory and stimulat more

Publications Internal Medicine

• Atrial fibrillation in young stroke patients: do we underestimate its prevalence?

  Background and purpose The prevalence of atrial fibrillation (AF) in young stroke patients has rarely been reported and is considered an uncommon ischaemic stroke (IS) aetiology. Our objective was to analyse the prevalence of AF in IS patients up to 50 years of age and its relationship with stro more

• Quantitative Analytical Method for Determining the Levels of Gastric Inhibitory Polypeptides GIP1–42 and GIP3–42 in Human Plasma Using LC–MS/MS/MS

  Gastric inhibitory polypeptide (GIP), an incretin, is an important subject in endocrinology. Some LC–MS assays have been proposed; however, their sensitivities are insufficient for the study of endogenous human incretin. Here, we describe a nanoflow LC hybrid triple quadrupole/linear ion trap MS ass more

• For the article |[lsquo]|Quality of reporting of randomization methodology in nephrology trials|[rsquo]|

  For the article ‘Quality of reporting of randomization methodology in nephrology trials’ Kidney International 83, 973 (May 2013). doi:10.1038/ki.2013.67 more

Market studies Internal Medicine

• Czech Republic Nephrology and Urology Devices Market Outlook to 2018 - Incontinence Devices, Renal Dialysis Equipment and Lithotripters

  Introduction GlobalData’s new report, “Czech Republic Nephrology and Urology Devices Market Outlook to 2018 - Incontinence Devices, Renal Dialysis Equipment and Lithotripters” provides key market data on the Czech Republic Nephrology and Urology Devices market. The report provides value (USD milli more

• Spain Nephrology and Urology Devices Market Outlook to 2018 - Incontinence Devices, Renal Dialysis Equipment and Lithotripters

  Introduction GlobalData’s new report, “Spain Nephrology and Urology Devices Market Outlook to 2018 - Incontinence Devices, Renal Dialysis Equipment and Lithotripters” provides key market data on the Spain Nephrology and Urology Devices market. The report provides value (USD million), volume (units more

• Israel Nephrology and Urology Devices Market Outlook to 2018 - Incontinence Devices, Renal Dialysis Equipment and Lithotripters

  Introduction GlobalData’s new report, “Israel Nephrology and Urology Devices Market Outlook to 2018 - Incontinence Devices, Renal Dialysis Equipment and Lithotripters” provides key market data on the Israel Nephrology and Urology Devices market. The report provides value (USD million), volume (uni more

Websites Internal Medicine