DNA Damage

News DNA Damage

• DNA damage: The dark side of respiration

  Adventitious changes in cellular DNA can endanger the whole organism, as they may lead to life-threatening illnesses like cancer. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich now report how byproducts of respiration cause mispairing of subunits in the double helix. The DNA in our c more

• Raman spectroscopic mapping for the analysis of solar radiation induced skin damage

  Working with an artificial skin model exposed to simulated solar irradiation, scientists in Ireland used Raman spectroscopic mapping to identify the dermal and stratum corneum layers in samples and distinguish further substructures of the epidermis. The authors were able to identify DNA damage, loss more

• Mitochondrial metabolic regulator SIRT4 guards against DNA damage

  Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them. Researchers studying a set of proteins that regulate physiology, caloric restriction and aging have discovered another important more

White papers DNA Damage

• Quantification of BRCA1 Expression Level Using Standard RT-PCR Reagents - a Sensitive Method for the Detection of Low Amounts of Transcripts
  

  Mutations in the breast cancer susceptibility gene, BRCA1, occur in the majority of families with multiple members affected with breast or ovarian cancer. Women who inherit a BRCA1 mutation have 40%-80% risk of developing breast cancer or ovarian cancer. However, up to 90% of breast cancers are sporadic, and mutations in BRCA1 seem to be a rare event in sporadic breast tumors. more

Publications DNA Damage

• Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis

  Primary microcephaly (PM) is a developmental disorder of early neuroprogenitors that results in reduction of the brain mass, particularly the cortex. To gain fresh insight into the pathogenesis of PM, we describe a consanguineous family with a novel genetic variant responsible for the disease. We p more

• The Co-Repressor SMRT Delays DNA Damage-Induced Caspase Activation by Repressing Pro-Apoptotic Genes and Modulating the Dynamics of Checkpoint Kinase 2 Activation

  by Claudio Scafoglio, Marcus Smolka, Huilin Zhou, Valentina Perissi, Michael G. Rosenfeld Checkpoint kinase 2 (Chk2) is a major regulator of DNA damage response and can induce alternative cellular responses: cell cycle arrest and DNA repair or programmed cell death. Here, we report the identifica more

• ATM–Dependent MiR-335 Targets CtIP and Modulates the DNA Damage Response

  by Nathan T. Martin, Kotoka Nakamura, Robert Davies, Shareef A. Nahas, Christina Brown, Rashmi Tunuguntla, Richard A. Gatti, Hailiang Hu ATM plays a critical role in cellular responses to DNA double-strand breaks (DSBs). We describe a new ATM–mediated DSB–induced DNA damage response path more

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