Dementia

News Dementia

• Cancer drug prevents build-up of toxic brain protein

  Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects. They say their study, publi more

• Suppressing protein may stem Alzheimer's disease process

  Scientists funded by the National Institutes of Health have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer's disease. It's based on unclogging removal of toxic debris that accumulates in patients' brains, by blocking activity of a little-known regu more

• Mild blast injury causes molecular changes in brain akin to Alzheimer

  A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer's disease. Their findings more

Publications Dementia

• Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story

  Publication date: Available online 14 May 2013 Source:Current Opinion in Chemical Biology Author(s): Andrew Stamford , Corey Strickland Several fragment-based methods have been applied to the discovery of new lead sources for inhibitors of BACE1, an important therapeutic target for Alzheimer more

• Baicalein reduces β‐amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model

  Baicalein, a flavonoid isolated from the roots of Scutellaria baicalensis, is known to modulate γ‐aminobutyric acid (GABA) type A receptors. Given prior reports demonstrating benefits of GABAA modulation for Alzheimer's disease (AD) treatment, we wished to determine whether this agent might be ben more

• The paradox of overnutrition in aging and cognition

  Populations of many countries are becoming increasingly overweight and obese, driven largely by excessive calorie intake and reduced physical activity; greater body mass is accompanied by epidemic levels of comorbid metabolic diseases. At the same time, individuals are living longer. The combinati more

Market studies Dementia

• Lewy body Dementia – Pipeline Review, H2 2012

  Introduction Global Markets Direct’s, 'Lewy body Dementia - Pipeline Review, H2 2012', provides an overview of the indication’s therapeutic pipeline. This report provides information on the therapeutic development for Lewy body Dementia, complete with latest updates, and special features on late-s more

• Exelon (Alzheimer’s disease) – Analysis and Forecasts to 2022

  Introduction GlobalData’s pharmaceuticals report, “Exelon (Alzheimer’s disease) – Analysis and Forecasts to 2022” provides Exelon global sales estimates. In addition, it covers detailed clinical assessment of the drug, factors impacting drug sales, competitive landscape, and analysis of sales perf more

• Alzheimer's Disease Global Clinical Trials Review, H2, 2012

  Introduction GlobalData's clinical trial report, “Alzheimer’s Disease Global Clinical Trials Review, H2, 2012" provides data on the Alzheimer’s Disease clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Alzheimer’s Disease. It includes a more

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