Confocal Microscopes

Products Confocal Microscopes

True Surface Microscopy - Chemical Imaging along with large area optical profiling

WITec's exclusive new True Surface Microscopy option makes it possible to perform confocal imaging measurements parallel with and guided by large area topographic scans more

Chemical 3D Imaging with Raman: ultrasensitive & fast, 200 nm resolution, upgradeable to AFM

The microscope series alpha300 and alpha500 allow to perform Confocal Raman Imaging for chemical 3D Imaging and Atomic Force Microscopy for high-resolution more

inVia - the most flexible Raman microscope for research applications

High-resolution confocal measurements (both spectral and spatial) are enabled with the integration of research-grade optical microscopes. This ultra-high performance more

News Confocal Microscopes

• The secret life of cells – in colour

  The 2011 Lennart Nilsson Award is to be presented to American biologist Nancy Kedersha, who is to receive the prize for her colour pictures showing the inner life of a cell.The panel’s citation reads as follows: “Nancy Kedersha’s colour images open our eyes to the smallest components of life. Throug more

• Cell Receptor Recycling Mechanism Discovery opens up New Class of Therapeutic Targets

  Prof. Manojkumar Puthenveedu of Carnegie Mellon University studies the mechanisms by which membrane trafficking controls and co-ordinates the complex signalling pathways in the brain. Despite the fact that almost all diseases can be traced to a defect in how cells respond to signals, little is known more

• New three-dimensional imaging method paves way for several research fields

  A new method for 3D imaging and quantification of biological preparations ten times larger than the limit for the traditional confocal microscope is now being presented by researchers from Umeå University in Sweden in the journal Nature Methods. Traditional biological imaging techniques are limited more

White papers Confocal Microscopes

• New Standard in Electrophysiology and Deep Tissue Imaging
  

  The function of nerve and muscle cells relies on ionic currents flowing through ion channels. These ion channels play a major role in cell physiology. One way to investigate ion channels is to use patch clamping. This method allows investigation of ion channels in detail and recording of the electric activity of different types of cells, mainly excitable cells like neurons, muscle fibres or beta cells of the pancreas. The patch clamping technique was developed by Erwin Neher and Bert Sakmann in the 1970s and 80s to study individual ion channels in living cells. In 1991 they received the Nobel Prize for Physiology and Medicine for their work. Today the patch clamping technique is one of the most important methods in the field of electrophysiology more

• Confocal Detection of NBT/BCIP In Situ Hybridization
  

  Confocal laser scanning reflection microscopy (CLSM) in combination with whole-mount in situ hybridization (WMISH) is a novel method to visualize gene expression patterns in three dimensions in whole embryos. The method uses conventional NBT/BCIP precipitation by alkaline phosphatase in WMISH samples and confocal detection by reflection microscopy. WMISH protocols can also be combined with fluorescent counterstainings such as DAPI, antibodies, GFP lines, and fluorescent in situ probes. Such double and triple labeling combined with confocal microscopy allows expression profiling at a cellular resolution in cell types or embryological structures of interest. Whole-mount reflection CLSM will thus greatly facilitate large-scale, cellular resolution expression profiling in vertebrate and invertebrate model organisms. more

• Structural and Chemical 3D Imaging with AFM and Raman.
  

  In the Life Sciences and Bio-medical Research, the characterization of chemical compounds within cells or tissues is one of the most important and difficult tasks for researchers to perform. The development of pharmaceuticals such as drug delivery coatings or capsules also requires as much information as possible about their chemical and structural compositions. For the fields of nanotechnology and materials science, a thorough knowledge of the samples' surface morphology on a sub-micron scale is essential more

Publications Confocal Microscopes

• Pro‐angiogenic potential of human chorion‐derived stem cells: in vitro and in vivo evaluation

  Abstract Human chorion‐derived stem cells (hCDSC) were previously shown to demonstrate multipotent properties with promising angiogenic characteristics in monolayer‐cell culture system. In our study, we investigated the angiogenic capability of hCDSC in 3‐dimensional (3D) in vitro and in vivo an more

• Microsurgical Approaches to Isolate Tissues from Xenopus Embryos for Imaging Morphogenesis

  To understand dynamic cell and tissue mechanics during Xenopus laevis morphogenesis requires the use of live reporters of cell architecture as well as reporters for the location and activity of proteins in cells within a multicellular tissue. Fluorescently tagged proteins are some of the most usefu more

• Astrocytic TRPV1 ion channels detect blood‐borne signals in the sensory circumventricular organs of adult mouse brains

  The circumventricular organs (CVOs), including the organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), and area postrema (AP) sense a variety of blood‐borne molecules because they lack typical blood‐brain barrier. Though a few signaling pathways are known, it is not known more

Market studies Confocal Microscopes

• Optiscan Imaging Limited (OIL) - Financial and Strategic SWOT Analysis Review

  Optiscan Imaging Limited (Optiscan Imaging) is a medical device company engaged in the development, manufacture and commercialization of miniaturized confocal microscopes and microscopic imaging technologies for medical markets. The principal product of the company is Pentax ISC 1000, a flexible end more

Websites Confocal Microscopes