Central Nervous System

News Central Nervous System

• New virus isolated from patients with severe brain infections

  Researchers have identified a new virus in patients with severe brain infections in Vietnam. Further research is needed to determine whether the virus is responsible for the symptoms of disease. The virus was found in a total of 28 out of 644 patients with severe brain infections in the study, corre more

• A better look into cerebrospinal fluid

  Cerebrospinal fluid (CSF) of the central nervous system disseminates numerous cells, proteins, microparticles, and DNA as potential biomarkers of many diseases and therapy efficacy. For example, circulating tumor cells are a sign for metastatic cancer, bacteria can reveal an infectious meningitis or more

• UCB and Proteros expand successful protein x-ray crystallography collaboration

  UCB and Proteros biostructures GmbH announced expansion of their ongoing structural biology collaboration to include additional therapeutic areas. Since 2007, Proteros has supported discovery programmes for UCB in the area of immunology, by solving complex unpublished protein structures to give UCB more

Publications Central Nervous System

• Peroxisome proliferator‐activated receptor gamma‐coactivator‐1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis

  Abstract Peroxisome proliferator‐activated receptor gamma‐coactivator‐1 alpha (PGC1a) is involved in energy and lipid metabolism, and its loss leads to neurodegenerative changes in the striatum. Here we performed lipidomic analysis on brain extracts from PGC1a mutant and wild‐type mice. We found more

• Developmental Hypothyroxinemia Induced by Maternal Mild Iodine Deficiency Delays Hippocampal Axonal Growth in the Rat Offspring

  Abstract Iodine is essential for the biosynthesis of thyroid hormones, including triiodothyronine and thyroxine. Thyroid hormones are important for central nervous system development. Mild maternal iodine deficiency (ID)‐induced hypothyroxinemia causes neurological deficits and mental retardatio more

• Exercise Challenge in Gulf War Illness Reveals Two Subgroups with Altered Brain Structure and Function

  by Rakib U. Rayhan, Benson W. Stevens, Megna P. Raksit, Joshua A. Ripple, Christian R. Timbol, Oluwatoyin Adewuyi, John W. VanMeter, James N. Baraniuk Nearly 30% of the approximately 700,000 military personnel who served in Operation Desert Storm (1990–1991) have developed Gulf War Illness, a con more

Market studies Central Nervous System

• Partnerships, Licensing, Investments and M&A Deals and Trends in Pharmaceuticals - February 2012

  Introduction GlobalData's “Partnerships, Licensing, Investments and M&A Deals and Trends in Pharmaceuticals - February 2012” report is an essential source of data and trend analysis on partnerships, licensing, mergers and acquisitions (M&As) and financings in the pharmaceuticals industry. The repor more

• Chile Pharmaceuticals and Healthcare Report Q3 2012

  BMI View: Chile’s intellectual property (IP) regime continues to be a cause of concern for the manufacturers of innovative pharmaceuticals, with the country listed on the Priority Watch List of the 2012 Special 301 report. While the data protection regime has been improved, concern remains over len more

• Protein and Peptide-based Therapeutics - Trends in Drug Discovery and Development

  GBI Research, leading business intelligence provider, has released its latest research report, entitled “Protein and Peptide-based Therapeutics - Trends in Drug Discovery and Development". Over the last decade, protein and peptide-based therapeutics have attracted more and more attention in the phar more

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