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Malaria is one of the most threatening infectious diseases in the world. An international team has now been able to investigate malaria pathogens in red blood cells in vivo using the BESSY II X-ray microscope and the ALBA and ESRF synchrotron sources. The scientists reveal the mechanisms used by act more
Malaria is one of the world's deadliest infectious diseases: a small mosquito bite delivers numerous malaria parasites into the bloodstream. The human body defends itself valiantly against the parasite, which usually results in periodic flu-like symptoms and severe fever. Severe cases of the disease more
Despite humanity's best efforts to eradicate malaria, the disease struck more than 200 million people in 2017, according to the World Health Organization. Worse yet, the parasite that causes malaria is developing resistance to many antimalarial drugs, including the mainstay, chloroquine. Researchers more
The Nobel Prize in Physiology or Medicine 2015 goes to William Campbell & Satoshi Ōmura "for their discoveries concerning a novel therapy against infections caused by roundworm parasites" and Youyou Tu "for her discoveries concerning a novel therapy against Malaria". more
Malaria Severe malaria is caused by the parasite Plasmodium falciparum . Infections can result in organ failure and life-threatening hematological or metabolic abnormalities. Lee et al. sequenced patient and parasite transcriptomes from 46 P. falciparum –infected Gambian children to better more
Immunology Affinity maturation in B cells generates antibodies with increasingly enhanced antigen-binding properties. Imkeller et al. investigated the maturation of human B cells that express protective antibodies against the circumsporozoite protein of the malaria-causing parasite Plasmodium more
by Ninja Ritter Klejnstrup, Julie Buhl-Wiggers, Sam Jones, John Rand Malaria is a major cause of morbidity and mortality in sub-Saharan Africa. It is also a dynamic contributor to poverty through its effects on children’s cognitive development. This paper examines the degree to which malaria in e more
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