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Mutations

News Mutations

  • Researchers uncover molecular mechanisms of rare skin disease

    Keratinocyte skin cells are common targets of the beta subtype of human papilloma virus. This usually harmless infection causes skin disease in people with rare gene mutations. You're probably infected with one or more subtypes of the human papilloma virus--and, as alarming as that may sound, odds a more

  • Mutation 'hotspots' in DNA could lead to new insights on cancer risks

    New research from Indiana University has identified "hotspots" in DNA where the risk for genetic mutations is significantly elevated. These mutations arise because "typos" can occur as DNA replicates during cellular division. A recent analysis, which found that random mistakes in DNA play a large ro more

  • System that reduces neurodegeneration in Huntington’s disease

    The neuroscientist Dr David Vilchez and his team at CECAD, the University of Cologne’s Cluster of Excellence for Aging Research, have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington’s disease. Particularly, they identified a system blo more

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Events Mutations

Conference
05-09 – 08-09
2018
Heidelberg, DE

EMBO | EMBL Symposium: Principles of Chromosome Structure and Function

Chromosomes are arguabely one of the most important structures inside cells. Several meters of DNA are compacted into micrometer-sized assemblies in every human cell. Recent advances in our understanding of how this is achieved, and of its implications on nuclear functions, have been breathtaking. I

Webinar
On-Demand

New Strategy to Identify Small Molecule Therapies: Usher Syndrome III Case Study

Characterized by progressive deafness, blindness and variable balance disorder, Usher syndrome type III (USH3) is caused by destabilizing mutations in the gene encoding the clarin-1 protein (CLRN1).

Webinar
On-Demand

Designing a Novel Cancer Drug: From Hit ID to Candidate

Many cancers exhibit dysregulation of the MAPK/ERK (MEK) signalling pathway driven by mutations in multiple enzymes within the pathway. Listen to our scientists describe a project to identify a novel, potent, selective small-molecule inhibitor targeting a specific kinase in this pathway.

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Definition

Mutation

Mutation In biology , mutations are changes to the base pair sequence of the genetic material of an organism. Mutations can be caused by copying errors in the genetic material during cell division , by exposure to ultraviolet or ionizing ra ... more

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