Metabolism

Services Metabolism

ADME-Tox Studies Benefit from Advances in Evaporative Sample Preparation

A new web page from Genevac brings together the latest technological innovations, applications advances and links to references that details how new more

News Metabolism

• Exercise-related changes in estrogen metabolism may lower breast cancer risk

  Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention. "Observational studies suggest physical activity lowers breast cancer risk, but there more

• New light shed on early stage Alzheimer's disease
  

  The disrupted metabolism of sugar, fat and calcium is part of the process that causes the death of neurons in Alzheimer's disease. Researchers from Karolinska Institutet have now shown, for the first time, how important parts of the nerve cell that are involved in the cell's energy metabolism operat more

• Blockade of pathogen's metabolism
  

  In the search for new antibiotics, researchers are taking an unusual approach: They are developing peptides, short chains of protein building blocks that effectively inhibit a key enzyme of bacterial metabolism. Now, scientists at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) i more

White papers Metabolism

• alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
  

  The alamarBlue® cell proliferation assay is based on a reducing environment that indicates metabolic active cells. Active cells are able to convert resazurin into the resorufin. Resazurin is blue and non-fluorescent whereas resorufin is red and highly fluorescent; therefore a fluorescent and a colorimetric detection are possible. This application notes focuses on the quantification of cell proliferation in a Human Osteoblast cell culture by measuring alamarBlue® fluorescence on the FLUOstar OPTIMA microplate reader more

• Assessing Microbial Metabolism Using A Simple ‘Mix & Measure’ Oxygen Consumption Assay
  

  MitoXpress® from Luxcel Biosciences is a water-soluble oxygen-sensitive phosphorescent probe that facilitates microplate based analysis of microbial oxygen consumption. The microbial metabolism implications of treatments such as drug exposure, genetic manipulation or altered cultured conditions can be easily accessed using BMG LABTECH´s FLUOstar Omega microplate reader to read both growth and oxygen consumption in parallel more

• Detection of NADH and NADPH with the Omega's High Speed, Full UV/Vis Absorbance Spectrometer
  

  Nicotinamide Adenine Dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), nicotinamide adenine dinucleotide phosphate (NADP+) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) have been known to play vital roles in energy metabolism, antioxidation, and reductive biosynthesis. In recent years, these co-factors have been shown to be involved in other physiological functions as well, including aging, oxidative stress, intracellular calcium homeostasis, ROS production, cell death and gene expression. more

Publications Metabolism

• Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing

  Abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including Alzheimer's disease. Aberrant alternative splicing of exon 10 in the tau pre-mRNA resulting in an imbalance of tau isoforms is one of the molecular causes of the inherited tauopathy, FTDP-17. W more

• Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells

  Small intestinal epithelial cells (sIECs) have a significant share in whole body metabolism as they perform enzymatic digestion and absorption of nutrients. Furthermore, the diet plays a key role in a number of complex diseases including obesity and diabetes. The impact of diet and altered genetic more

• Influence of mild and moderate liver impairment on the pharmacokinetics and metabolism of almorexant, a dual orexin receptor antagonist

  Publication date: Available online 11 June 2013 Source:European Journal of Pharmaceutical Sciences Author(s): Kasra Shakeri-Nejad , Matthias Hoch , Petra Hoever , Jasper Dingemanse This single-dose study aimed at investigating the effect of different degrees of hepatic impairment on the ph more

Market studies Metabolism

• Bone Metabolism Therapeutics Market to 2018 - Hyperparathyroidism Sector to Decline in the Absence of New Product Launches and Increased Generic Erosion for Zemplar, Hectorol a ...

  GBI Research, the leading business intelligence provider, has released its latest research, “Bone Metabolism Therapeutics Market to 2018 - Hyperparathyroidism Sector to Decline in the Absence of New Product Launches and Increased Generic Erosion for Zemplar, Hectorol and Sensipar”, which provides in more

• Diagnostic Imaging Market to 2017 - Fusion Technology to Increase Adoption Rates of Hybrid Imaging Systems

  GBI Research’s report, “Diagnostic Imaging Market to 2017 - Fusion Technology to Increase Adoption Rates of Hybrid Imaging Systems” provides information and analysis on the global diagnostic imaging market. The report provides market landscape, competitive landscape and market trends information on more

• Searle Pakistan Limited - Strategic SWOT Analysis Review

  Searle Pakistan Limited (SPL) is a Pakistan-based pharmaceutical company engaged in the manufacture, sale, and distribution of pharmaceutical products and a low calorie sweetener to the healthcare and consumer industries. The company develops products in various dosage forms of coated and uncoated t more

Websites Metabolism