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New Parsum probe - fit for purpose PAT for granulation particle size monitoring

Particle size distribution is one of the key parameters in pharmaceutical powder processing. Granulation – a common method for improving powder flow properties and reducing segregation is often not easy to develop, scale-up and control. Fluid Bed top spray granulation – monitor granule growth Wurste


Understanding Dissolution Inconsistency Through In Situ Particle Characterization and Root Cause Analysis

Dissolution and disintegration testing are well established as standard analytical tests used during pharmaceutical development. Yet, if dissolution is inconsistent, what is the root cause? Was the internal tablet or capsule structure inconsistent? Were the particle disintegration and erosion mechan


Optimization of High Shear Wet Granulation

High shear wet granulation is a common unit operation in solid dosage formulation, yet a mechanistic understanding is not well known. One goal of high shear granulation is to yield a repeatable granule size and granule shape distribution at the batch endpoint. This is necessary for consistent downst

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Arachnoid granulation

Arachnoid granulation Arachnoid granulations (or arachnoid villi) are small protrusions of the arachnoid (the thin second layer covering the brain) through the dura (the thick outer layer). They protrude into the venous sinuses of the brain, ... more


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