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Nothing works without the correct form: For most proteins, there are millions of ways in which these molecules, composed of long chains of amino acids, can be folded - but only one way is the right one. Researchers in the department "Cellular Biochemistry" at the Max Planck Institute for Biochemistry in Martinsried examine how this origami in cells works and what happens if something goes awry. Franz Ulrich Hartl and his team are interested in both the underlying mechanisms and the structure of the molecules involved.
Epigenetics - packaging artists in the cell
Methyl attachments to histone proteins determine the degree of packing of the DNA molecule. They thereby determine whether a gene can be read or not. In this way, environment can influence the traits of an organism over generations. more
Biomaterials - patent solutions from nature
Animals and plants can produce amazing materials such as spider webs, wood or bone using only a few raw materials available. How do they achieve this? And what can engineers learn from them? more
The discovery that bacteria use a kind of immune system to fight viruses initially was only interesting for microbiologists. But when the discovery that CRISPR/Cas9 system is able to manipulate genes of many organisms was made, also non-scientists were alerted. But how does this method works? more
Only one in three fertilizations leads to a successful pregnancy. Many embryos fail to progress beyond early development. Cell biologists at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen (Germany), together with researchers at the Institute of Farm Animal Genetics in ... more
DNA building blocks regulate inflammation
Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell. The reasons for the release are not yet known, but some cardiac and neurodegenerative dis ... more
More than the sum of mutations
A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers in Berlin combined a wide variety of data, analyzed it with “Artificial Intelligence” and identified numerous cancer genes. This opens up new perspectives for targeted canc ... more
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
The research institutes of the Max Planck Society perform basic research in the interest of the general public in the natural sciences, life sciences, social sciences, and the humanities. In particular, the Max Planck Society takes up new and innovative research areas that German universiti ... more
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