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Nothing works without the correct form: For most proteins, there are millions of ways in which these molecules, composed of long chains of amino acids, can be folded - but only one way is the right one. Researchers in the department "Cellular Biochemistry" at the Max Planck Institute for Biochemistry in Martinsried examine how this origami in cells works and what happens if something goes awry. Franz Ulrich Hartl and his team are interested in both the underlying mechanisms and the structure of the molecules involved.
Epigenetics - packaging artists in the cell
Methyl attachments to histone proteins determine the degree of packing of the DNA molecule. They thereby determine whether a gene can be read or not. In this way, environment can influence the traits of an organism over generations. more
Biomaterials - patent solutions from nature
Animals and plants can produce amazing materials such as spider webs, wood or bone using only a few raw materials available. How do they achieve this? And what can engineers learn from them? more
The discovery that bacteria use a kind of immune system to fight viruses initially was only interesting for microbiologists. But when the discovery that CRISPR/Cas9 system is able to manipulate genes of many organisms was made, also non-scientists were alerted. But how does this method works? more
Circular RNA makes fruit flies live longer
Ribonucleic acid, or RNA, is part of our genetic code and present in every cell of our body. The best known form of RNA is a single linear strand, of which the function is well known and characterized. But there is also another type of RNA, so-called “circular RNA”, or circRNA, which forms ... more
Neandertal genes in the petri dish
Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary ti ... more
Proteins control life as one of the most important biomolecules - as enzymes, receptors, signal or structural building blocks. Researchers at the Max Planck Institute (MPI) of Biochemistry have for the first time uncovered the proteomes of 100 different organisms. The selected specimens com ... more
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
The research institutes of the Max Planck Society perform basic research in the interest of the general public in the natural sciences, life sciences, social sciences, and the humanities. In particular, the Max Planck Society takes up new and innovative research areas that German universiti ... more
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