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213 Newest Publications about the topic x-ray crystallography


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3.5Å cryoEM Structure of Hepatitis B Virus Core Assembled from Full-Length Core Protein

06-Sep-2013 | Xuekui Yu et al., PLoS ONE, 2013

by Xuekui Yu, Lei Jin, Jonathan Jih, Chiaho Shih, Z. Hong Zhou The capsid shell of infectious hepatitis B virus (HBV) is composed of 240 copies of a single protein called HBV core antigen (HBc). An atomic model of a core assembled from truncated HBc was determined previously by X-ray ...


Evolution of Substrate Specificity in a Recipient’s Enzyme Following Horizontal Gene Transfer

01-Sep-2013 | Lianet Noda-García; Aldo R. Camacho-Zarco; Sofía Medina-Ruíz; Paul Gaytán; Mauricio Carrillo-Tripp; Vilmos Fülöp; Fr ..., Molecular Biology and Evolution, 2013

Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function. Specifically, what is the influence of a recently acquired gene on the function of an existing gene? For example, certain ...


Predicting protein‐DNA interactions by full search computational docking

22-Aug-2013 | Victoria A. Roberts, Michael E. Pique, Lynn F. Ten Eyck, Sheng Li, Proteins: Structure, Function, and Bioinformatics, 2013

Abstract Protein‐DNA interactions are essential for many biological processes, X‐ray crystallography can provide high‐resolution structures, but protein‐DNA complexes are difficult to crystallize and typically contain only small DNA fragments. Thus, there is a need for computational methods ...


X‐ray crystallographic and fluorometric analysis of the interactions of Rhein to Human Serum Albumin

20-Aug-2013 | M Li, P Lee, Y Zhang, ZY Ma, F Yang, ZP Zhou, XY Wu, H Liang, Chemical Biology & Drug Design, 2013

Abstract To investigate the interactions between natural drugs and human serum albumin (HSA), we performed fluorescence spectroscopy and X‐ray crystallography to gain insight into binding mechanism and behavior of rhein to HSA. Our fluorescence results demonstrated that rhein strongly binds ...


Synthesis and Crystal Structure of Anhydrous Analog of 1,25‐Dihydroxyvitamin D3

15-Aug-2013 | Anita Pietraszek, Maura Malińska, Michał Chodyński, Jacek Martynow, Małgorzata Krupa, Wioleta Maruszak, Krzysztof Wo ..., Journal of Pharmaceutical Sciences, 2013

As predicted by single crystal X‐ray crystallography, and contrary to the reported suggestions, the anhydrous form of calcipotriol, a therapeutically important vitamin D analog, was found stable enough to be used as an active pharmaceutical ingredient. The crystal and molecular structure of ...


RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation

15-Aug-2013 | Christian Mirschberger; Christian B. Schiller; Michael Schräml; Nikolaos Dimoudis; Thomas Friess; Christian A. Gerde ..., Cancer Research, 2013

The EGF receptor (EGFR) HER3 is emerging as an attractive cancer therapeutic target due to its central position in the HER receptor signaling network. HER3 amplifies phosphoinositide 3-kinase (PI3K)–driven tumorigenesis and its upregulation in response to other anti-HER therapies has been ...


Protein models: The grand challenge of protein docking

12-Aug-2013 | Ivan Anishchenko, Petras J. Kundrotas, Alexander V. Tuzikov, Ilya A. Vakser, Proteins: Structure, Function, and Bioinformatics, 2013

ABSTRACT Characterization of life processes at the molecular level requires structural details of protein‐protein interactions (PPI). The number of experimentally determined protein structures accounts only for a fraction of known proteins. This gap has to be bridged by modeling, typically ...


Investigation of DNA sequence recognition by a streptomycete MarR family transcriptional regulator through surface plasmon resonance and X-ray crystallography

01-Aug-2013 | Clare E. M. Stevenson; Aoun Assaad; Govind Chandra; Tung B. K. Le; Sandra J. Greive; Mervyn J. Bibb; David M. Lawson, Nucleic Acids Research, 2013

Consistent with their complex lifestyles and rich secondary metabolite profiles, the genomes of streptomycetes encode a plethora of transcription factors, the vast majority of which are uncharacterized. Herein, we use Surface Plasmon Resonance (SPR) to identify and delineate putative operator ...


Structure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology

23-Jul-2013 | Chao Zhang; Michael S. Lopez; Arvin C. Dar; Eva LaDow; Steven Finkbeiner; Cai-Hong Yun; Michael J. Eck; Kevan M. Shokat, ACS Chemical Biology, 2013

Engineered analog-sensitive (AS) protein kinases have emerged as powerful tools for dissecting phospho-signaling pathways, for elucidating the cellular function of individual kinases, and for deciphering unanticipated effects of clinical therapeutics. A crucial and necessary feature of this ...


Calcaripeptides A–C, Cyclodepsipeptides from a Calcarisporium Strain

18-Jul-2013 | Johanna Silber; Birgit Ohlendorf; Antje Labes; Christian Näther; Johannes F. Imhoff, Journal of Natural Products, 2013

The isolation and structure elucidation of the novel calcaripeptides A (1), B (2), and C (3) and studies on their biosynthetic origin are described. The calcaripeptides were identified from Calcarisporium sp. strain KF525, which was isolated from the German Wadden Sea. Compounds 1–3 are ...


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