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12 Newest Publications about the topic uterine fibroids


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African genetic ancestry interacts with body mass index to modify risk for uterine fibroids

17-Jul-2017 | Ayush Giri; Todd L. Edwards; Katherine E. Hartmann; Eric S. Torstenson; Melissa Wellons; Pamela J. Schreiner; Digna ..., PLoS Genetics, 2017

by Ayush Giri, Todd L. Edwards, Katherine E. Hartmann, Eric S. Torstenson, Melissa Wellons, Pamela J. Schreiner, Digna R. Velez Edwards Race, specifically African ancestry, and obesity are important risk factors for uterine fibroids, and likely interact to provide the right conditions for ...


Application of a Patient Derived Xenograft Model for Predicative Study of Uterine Fibroid Disease

20-Nov-2015 | Martin Fritsch et al., PLoS ONE, 2015

by Martin Fritsch, Nicole Schmidt, Ina Gröticke, Anna-Lena Frisk, Christopher S. Keator, Markus Koch, Ov D. Slayden Human uterine fibroids, benign tumors derived from the smooth muscle layers of the uterus, impose a major health burden to up to 50% of premenopausal women in their daily life. To ...


Utility values for pre-menopausal women suffering from symptomatic uterine fibroids

04-Oct-2014 | Marg Hux; Carita Ng; Greta Lozano Ortega; Simon Ferrazzi; Ron Goeree, Expert Review of Pharmacoeconomics & Outcomes Research, 2014

Background: Uterine fibroids (UF) represent the most common benign uterine tumor in women of reproductive age. Symptoms including heavy, prolonged menstrual bleeding, pelvic pain/pressure, and/or urinary frequency have a substantial impact on women's quality of life and utility values for UF have ...


No REST for fibroids [Developmental Biology]

05-Feb-2013 | Bo R. Rueda; John S. Davis, Proceedings of the National Academy of Sciences current issue, 2013

Good news: A long-awaited model for uterine fibroid tumor research is upon us (1). Historically, there has been a paucity of in vivo models for the study of fibroid tumors (i.e., leiomyomas), benign female pelvic organ tumors characterized by clonal proliferation of smooth muscle cells and ...


Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway [Developmental Biology]

05-Feb-2013 | Binny V. Varghese; Faezeh Koohestani; Michelle McWilliams; Arlene Colvin; Sumedha Gunewardena; William H. Kinsey; Ro ..., Proceedings of the National Academy of Sciences current issue, 2013

Uterine fibroids (leiomyomas) are the most common tumors of the female reproductive tract, occurring in up to 77% of reproductive-aged women, yet molecular pathogenesis remains poorly understood. A role for atypically activated mammalian target of rapamycin (mTOR) pathway in the pathogenesis of ...


A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids

03-Apr-2011 | Pei-Chieng Cha; Atsushi Takahashi; Naoya Hosono; Siew-Kee Low; Naoyuki Kamatani; Michiaki Kubo; Yusuke Nakamura, Nature Genetics, 2011

A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids Nature Genetics 43, 447 (2011). doi:10.1038/ng.805 Authors: Pei-Chieng Cha, Atsushi Takahashi, Naoya Hosono, Siew-Kee Low, Naoyuki Kamatani, Michiaki Kubo & Yusuke ...


IL6 and TNF expression in vessels and surrounding tissues after embolization with ibuprofen-loaded beads confirms diffusion of ibuprofen

16-Feb-2011 | Valentin, Verret , Claudia, Bevilacqua , Isabelle, Schwartz-Cornil , Jean-Pierre, Pelage , Michel, Wassef , ..., European Journal of Pharmaceutical Science, 2011

Purpose:: In the treatment of uterine fibroid embolization related pain, the use of embolics loaded with non-steroidal anti-inflammatory drugs (NSAID) relies on an efficient delivery and impregnation of the embolized tissue. Immuno-labelling and spectroscopic techniques have demonstrated the ...


Semiparametric Bayes' Proportional Odds Models for Current Status Data with Underreporting

22-Dec-2010 | Wang, Lianming; Dunson, David B., Biometrics, 2010

Summary Current status data are a type of interval‐censored event time data in which all the individuals are either left or right censored. For example, our motivation is drawn from a cross‐sectional study, which measured whether or not fibroid onset had occurred by the age of an ultrasound exam ...


ExAblate® magnetic resonance-guided focused ultrasound system in multiple body applications

07-Sep-2010 | EA Dick; WMW Gedroyc, Expert Review of Medical Devices, 2010

Focused ultrasound surgery (FUS) is a completely noninvasive method of thermally destroying a target tissue while sparing adjacent tissues and organs. Treatment is relatively painless and can be carried out under conscious sedation on an out-patient basis. The combination of magnetic resonance ...


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