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146 Newest Publications about the topic umbilical cord blood


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Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease

22-May-2018 | YongHwan Kim; Hye Jin Jin; Jinbeom Heo; Hyein Ju; Hye-Yeon Lee; Sujin Kim; Seungun Lee; Jisun Lim; Sang Young Jeong; ..., Leukemia, 2018

Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs primed with Hypoxia and Calcium ions (SHC-MSCs) exhibit enhanced stemness and immunomodulatory functions for treating ...


Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue

20-May-2018 | Author(s): J.J.M. Freriksen, D. Feyaerts, P.H.H. van den Broek, O.W.H. van der Heijden, J. van Drongelen, ..., European Journal of Pharmaceutical Science, 2018

Publication date: 1 July 2018 Source:European Journal of Pharmaceutical Sciences, Volume 119 Author(s): J.J.M. Freriksen, D. Feyaerts, P.H.H. van den Broek, O.W.H. van der Heijden, J. van Drongelen, H.W. van Hamersvelt, F.G.M. Russel, R.G. van der Molen, R. Greupink ...


Foxp3 expression in induced T regulatory cells derived from human umbilical cord blood vs. adult peripheral blood

09-May-2018 | Jeong-su Do; Fei Zhong; Alex Y. Huang; Wouter J. Van’t Hof; Marcie Finney; Mary J. Laughlin, Bone Marrow Transplantation, 2018

Foxp3 is essential for T regulatory cell (Treg) function. Broad complex-Tramtrack-Bric-a-brac domain (BTB) and Cap‘n’collar (CNC) homology 1, transcription factor 2 (BACH2) stabilizes Treg immune homeostasis in murine studies. However, little is known regarding what role, if any, BACH2 may have ...


Impaired thymopoiesis predicts for a high risk of severe infections after reduced intensity conditioning without anti-thymocyte globulin in double umbilical cord blood transplantation

09-Feb-2018 | Lucia E. Duinhouwer; Nick Beije; Bronno Holt; Anita Rijken-Schelen; Cor H. Lamers; Judith Somers; Eric Braakman; Jan ..., Bone Marrow Transplantation, 2018

Umbilical cord blood stem cell transplantation (UCBT) is associated with retarded hematopoietic recovery and immune reconstitution and a high infection-related morbidity and mortality, especially after conditioning including anti-thymocyte globulin (ATG). However, data on immune recovery, ...


Analysis of the Spanish CCR5-∆32 inventory of cord blood units: lower cell counts in homozygous donors

06-Feb-2018 | Emma Enrich; Francisco Vidal; Francisco Sánchez-Gordo; Juan M. Gómez-Zumaquero; Antonio Balas; Francesc Ru ..., Bone Marrow Transplantation, 2018

The possibility to use CCR5-∆32 umbilical cord blood to cure HIV infection in patients in need of a hematopoietic transplant has been suggested. The less stringent HLA compatibility needed in this type of transplant facilitates the search of a suitable donor having the CCR5-∆32 mutation. To ...


Differences between Platelets Derived from Neonatal Cord Blood and Adult Peripheral Blood Assessed by Mass Spectrometry

30-Aug-2017 | Eva Stokhuijzen; Johanna Maria Koornneef; Benjamin Nota; Bart Laurens van den Eshof; Floris Pieter Joachim van Alphe ..., Journal of Proteome Research, 2017

It has been proposed that differences may exist between umbilical cord blood (CB) platelets and adult peripheral blood (APB) platelets, including altered protein levels of the main platelet integrins. We have now compared the protein expression profiles of CB and APB platelets employing a ...


Mammalian blastocyst mimicry

12-Jul-2017 | Niccolò Bianchi, Marianna Longo, CarloAlberto Redi, Manuela Monti, Molecular Reproduction and Development, 2017

Abstract A gradual restriction in stem cells potency is observed during the different stages of mammalian embryonic development, starting with the zygote, the totipotent stem cell par excellence, up to the blastocyst stage. Stem cells of the inner cell mass are endowed with pluripotent ...


Fetal hemoglobin in umbilical cord blood in preeclamptic and normotensive pregnancies: A cross-sectional comparative study

28-Apr-2017 | Zahra Masoumi; Mary Familari; Karin Källén; Jonas Ranstam; Per Olofsson; Stefan R. Hansson, PLoS ONE, 2017

by Zahra Masoumi, Mary Familari, Karin Källén, Jonas Ranstam, Per Olofsson, Stefan R. Hansson Preeclampsia (PE) is associated with increased fetal hemoglobin (HbF) in the maternal circulation but its source is unknown. To investigate whether excessive HbF is produced in the placenta or the ...


Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns

24-Feb-2017 | Paul S. Stadem; Megan V. Hilgers; Derrick Bengo; Sarah E. Cusick; Susan Ndidde; Tina M. Slusher; Troy C. Lund, PLoS ONE, 2017

by Paul S. Stadem, Megan V. Hilgers, Derrick Bengo, Sarah E. Cusick, Susan Ndidde, Tina M. Slusher, Troy C. Lund Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that affects as many as 400 million people worldwide, making it the most common enzymatic defect. Subjects ...


The soluble cytoplasmic tail of CD45 (ct‐CD45) in human plasma contributes to keep T cells in a quiescent state

08-Oct-2016 | Alexander Puck, Stefan Hopf, Madhura Modak, Otto Majdic, Petra Cejka, Stephan Blüml, Klaus Schmetterer, Catharina Ar ..., European Journal of Immunology, 2016

The cytoplasmic tail of CD45 (ct‐CD45) is proteolytically cleaved and released upon activation of human phagocytes. It acts on T cells as an inhibitory, cytokine‐like factor in vitro. Here we show, that ct‐CD45 is abundant in human peripheral blood plasma from healthy adults compared with plasma ...


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