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170 Newest Publications about the topic traumatic brain injuries

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Prediction of on‐road driving ability after traumatic brain injury and stroke

05-Apr-2013 | P. M. Aslaksen, M. Ørbo, R. Elvestad, C. Schäfer, A. Anke, European Journal of Neurology, 2013

Background and purpose The aim of the study was to examine the predictive value of widely used standardized neuropsychological tests in a clinical setting for on‐road driving performance in patients with cerebral stroke or traumatic brain injury (TBI), and to provide cut‐off values for ...

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Administration of MS‐275 Improves Cognitive Performance and Reduces Cell Death Following Traumatic Brain Injury in Rats

29-Mar-2013 | Peng Cao, Yong Liang, Xu Gao, Ming‐Guang Zhao, Guo‐Biao Liang, CNS Neuroscience & Therapeutics, 2013

Summary Aims The MS‐275 is a selective inhibitor of class I histone deacetylases (HDACs), which has been reported as a potential strategy in some central nervous system diseases associated with neurodegeneration and disturbed learning. However, its role in traumatic brain injury is not well ...

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Chemical Interrogation of the Neuronal Kinome Using a Primary Cell-Based Screening Assay

19-Mar-2013 | Hassan Al-Ali; Stephan C. Schürer; Vance P. Lemmon; John L. Bixby, ACS Chemical Biology, 2013

A fundamental impediment to functional recovery from spinal cord injury (SCI) and traumatic brain injury is the lack of sufficient axonal regeneration in the adult central nervous system. There is thus a need to develop agents that can stimulate axon growth to re-establish severed connections. ...

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The Emerging Use of Ketamine for Anesthesia and Sedation in Traumatic Brain Injuries

11-Mar-2013 | Lee C. Chang, Sally R. Raty, Jaime Ortiz, Neil S. Bailard, Sanjay J. Mathew, CNS Neuroscience & Therapeutics, 2013

Summary Background Traditionally, the use of ketamine for patients with traumatic brain injuries is contraindicated due to the concern of increasing intracranial pressure (ICP). These concerns, however, originated from early studies and case reports that were inadequately controlled and ...

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Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat

05-Mar-2013 | J. Flygt, A. Djupsjö, F. Lenne, N. Marklund, European Journal of Neuroscience, 2013

Abstract Axonal injury is an important contributor to the behavioral deficits observed following traumatic brain injury (TBI). Additionally, loss of myelin and/or oligodendrocytes can negatively influence signal transduction and axon integrity. Apoptotic oligodendrocytes, changes in the ...

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Peptidergic drugs for the treatment of traumatic brain injury

28-Feb-2013 | X Antón Álvarez; Jesús Figueroa; Dafin Muresanu, Future Neurology, 2013

Traumatic brain injury (TBI) is a devastating medical condition that has an enormous socioeconomic impact because it affects more than 10 million people annually worldwide and is associated with high rates of hospitalization, mortality and disability. Although TBI survival has improved ...

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The effect of female sexual hormones on the intestinal and serum cytokine response after traumatic brain injury: different roles for estrogen receptor subtypes

21-Feb-2013 | Mohammad Khaksari, Zakieh Keshavarzi, Ahmad Gholamhoseinian, Bahram Bibak, Canadian Journal of Physiology and Pharmacology, 2013

Notre objectif consistait à évaluer l’effet des hormones sexuelles secondaires femelles sur l’expression des cytokines intestinales et sériques à la suite d’un traumatisme cérébral (TC). Des rats femelles adultes ont subi une ovariectomie et ont été réparties en 9 groupes : (i) faux traitement, ...

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Increased expression of AGS3 in rat brain cortex after traumatic brain injury

13-Feb-2013 | Wei Wang, Qi Li, Feihui Zou, Zhihua Yu, Yunfeng Wang, Ting Lu, Tong Hu, Gang Cui, Journal of Neuroscience Research, 2013

Abstract Receptor‐independent activators of G protein signaling (AGS) offer alternative modes of signal processing for the G protein signaling system that has broad mechanistic and functional significance. Previous studies have demonstrated that AGS3, which belongs to the AGS family, is ...

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Enzogenol for cognitive functioning in traumatic brain injury: a pilot placebo‐controlled RCT

05-Feb-2013 | A. Theadom, S. Mahon, S. Barker‐Collo, K. McPherson, E. Rush, A. C. Vandal, V. L. Feigin, European Journal of Neurology, 2013

Background and purpose Enzogenol, a flavonoid‐rich extract from Pinus radiata bark with antioxidant and anti‐inflammatory properties has been shown to improve working memory in healthy adults. In traumatic brain injury (TBI), oxidation and inflammation have been linked to poorer cognitive ...

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Divide and Conquer: Functional Segregation of Synaptic Inputs by Astrocytic Microdomains Could Alleviate Paroxysmal Activity Following Brain Trauma

24-Jan-2013 | Vladislav Volman et al., PLoS Computational Biology, 2013

by Vladislav Volman, Maxim Bazhenov, Terrence J. Sejnowski Traumatic brain injury often leads to epileptic seizures. Among other factors, homeostatic synaptic plasticity (HSP) mediates posttraumatic epileptogenesis through unbalanced synaptic scaling, partially compensating for the ...

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