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170 Newest Publications about the topic traumatic brain injuries


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Brain perfusion SPECT provides new insight on neurobiological effects of hyperbaric hyperoxia

25-Jun-2013 | Silvia Morbelli, Dario Arnaldi, Acta Physiologica, 2013

Oxygen delivered in supraphysiological amounts (hyperoxia) is under investigation as a therapy for severe traumatic brain injury and stroke (Liu etal 2011). In particular, traumatic brain injury is thought to be associated with a reduction of aerobic metabolism due to a variable combination of ...


Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury [Medical Sciences]

25-Jun-2013 | Jie Lu; Jason M. Frerich; L. Christine Turtzo; Siqi Li; Jeffrey Chiang; Chunzhang Yang; Xiaoping Wang; Chao Zhang; C ..., Proceedings of the National Academy of Sciences current issue, 2013

Acute traumatic brain injury (TBI) is associated with long-term cognitive and behavioral dysfunction. In vivo studies have shown histone deacetylase inhibitors (HDACis) to be neuroprotective following TBI in rodent models. HDACis are intriguing candidates because they are capable of provoking ...


Mortality of subjects with alcohol‐related seizures increased after alcohol cheapening

07-Jun-2013 | K. Vaaramo, J. Puljula, S. Tetri, S. Juvela, M. Hillbom, Acta Neurologica Scandinavica, 2013

Objective To investigate whether the reduction of alcohol prices in Finland (March 1, 2004) associated with an increase in mortality of subjects with alcohol‐related seizures. Patients and methods All subjects with head trauma in Oulu University Hospital during 1999 (n=827) were ...


Biomarkers for the Clinical Differential Diagnosis in Traumatic Brain Injury—A Systematic Review

27-May-2013 | Shoji Yokobori, Khadil Hosein, Stephen Burks, Ishna Sharma, Shyam Gajavelli, Ross Bullock, CNS Neuroscience & Therapeutics, 2013

Summary Rapid triage and decision‐making in the treatment of traumatic brain injury (TBI) present challenging dilemma in “resource poor” environments such as the battlefield and developing areas of the world. There is an urgent need for additional tools to guide treatment of TBI. The aim of ...


Neurobiological insight into hyperbaric hyperoxia

21-May-2013 | Alessandro Micarelli, Hans Jacobsson, Stig A Larsson, Cathrine Jonsson, Marco Pagani, Acta Physiologica, 2013

Abstract Aim Hyperbaric hyperoxia (HBO) is known to modulate aerobic metabolism, vasoreactivity and blood flow in the brain. Nevertheless, mechanisms underlying its therapeutic effects, especially in traumatic brain injury (TBI) and stroke patients, are debated. The present study aimed at ...


Therapeutic time window of noninvasive brain stimulation for pain treatment: inhibition of maladaptive plasticity with early intervention

14-May-2013 | Dafne C Andrade; Igor Borges; Gabriela L Bravo; Nadia Bolognini; Felipe Fregni, Expert Review of Medical Devices, 2013

Neuromodulatory effects of noninvasive brain stimulation (NIBS) have been extensively studied in chronic disorders such as major depression, chronic pain and stroke. However, few studies have explored the use of these techniques in acute conditions. A possible use of NIBS in acute disorders is to ...


Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing [METHOD]

01-May-2013 | Kasandra Lovette Burgos; Ashkan Javaherian; Roberto Bomprezzi; Layla Ghaffari; Susan Rhodes; Amanda Courtright; Waib ..., RNA, 2013

There has been a growing interest in using next-generation sequencing (NGS) to profile extracellular small RNAs from the blood and cerebrospinal fluid (CSF) of patients with neurological diseases, CNS tumors, or traumatic brain injury for biomarker discovery. Small sample volumes and samples with ...


Traumatic brain injury induces macrophage subsets in the brain

30-Apr-2013 | Christine L. Hsieh, Charles C. Kim, Bryan E. Ryba, Erene C. Niemi, Jennifer K. Bando, Richard M. Locksley, Jialing L ..., European Journal of Immunology, 2013

Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI‐induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased ...


Predicting health‐related quality of life 2 years after moderate‐to‐severe traumatic brain injury

29-Apr-2013 | M. V. Forslund, C. Roe, S. Sigurdardottir, N. Andelic, Acta Neurologica Scandinavica, 2013

Aims To describe health‐related quality of life (HRQL) 2years after moderate‐to‐severe traumatic brain injury (TBI) and to assess predictors of HRQL. Materials and methods A prospective cohort study of 91 patients, aged 16–55years, admitted with moderate‐to‐severe TBI to a trauma ...


Diffuse traumatic brain injury and the sensory brain

23-Apr-2013 | Dasuni S Alwis, Victoria Johnstone, Edwin Yan, Ramesh Rajan, Clinical and Experimental Pharmacology and Physiology, 2013

Summary In this review, we discuss the consequences to the brain's cortex, specifically to the sensory cortex, of traumatic brain injury. The thesis underlying this approach is that long‐term deficits in cognition seen after brain damage in humans are likely underpinned by an impaired ...


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