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1,081 Newest Publications about the topic transgenic mice

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Separate functional properties of NMDARs regulate distinct aspects of spatial cognition [RESEARCH]

01-Jun-2018 | Erin M. Sanders; Akua O. Nyarko-Odoom; Kevin Zhao; Michael Nguyen; Hong Hong Liao; Matthew Keith; Jane Pyon; Alyssa ..., Learning & Memory, 2018

N-methyl-d-aspartate receptors (NMDARs) at excitatory synapses are central to activity-dependent synaptic plasticity and learning and memory. NMDARs act as ionotropic and metabotropic receptors by elevating postsynaptic calcium concentrations and by direct intracellular protein signaling. In the ...

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Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

18-May-2018 | Zhana Haimon; Alon Volaski; Johannes Orthgiess; Sigalit Boura-Halfon; Diana Varol; Anat Shemer; Simon Yona; Binyamin ..., Nature Immunology, 2018

Transcriptome profiling is widely used to infer functional states of specific cell types, as well as their responses to stimuli, to define contributions to physiology and pathophysiology. Focusing on microglia, the brain’s macrophages, we report here a side-by-side comparison of classical ...

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Glutamatergic and gabaergic ventral BNST neurons differ in their physiological properties and responsiveness to noradrenaline

20-Apr-2018 | Nur Zeynep Gungor; Ryo Yamamoto; Denis Pare, Neuropsychopharmacology, 2018

The bed nucleus of the stria terminalis (BNST) regulates defensive responses to threats and its anteroventral portion (BNST-AV) is involved. BNST-AV contains a minority of glutamatergic neurons scattered among a dominant population of GABAergic cells. There is evidence that these two cell types ...

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An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo

17-Apr-2018 | Koichi Tomoshige; Minzhe Guo; Tomoshi Tsuchiya; Takuya Fukazawa; Iris M. Fink-Baldauf; William D. Stuart; Yoshio Nao ..., Oncogene, 2018

EGFR ligands (e.g., EGF and TGFA) have been shown to be clinically associated with poor survival in lung cancer. Since TGFA itself initiates autochthonous tumors in liver, breast, and pancreas but not in the lung in transgenic mice in vivo, it would appear that an EGFR ligand may not initiate but ...

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Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice

29-Mar-2018 | Yao Q, Feng M, Yang B, et al., Acta Biochimica et Biophysica Sinica, 2018

Abstract Epidemiologic studies have demonstrated that women account for two-thirds of Alzheimer’s disease (AD) cases, for which the decline in circulating gonadal hormone is considered to be one of the major risk factors. In addition, ovarian hormone deficiency may affect β-amyloid (Aβ) ...

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mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell

27-Mar-2018 | Brandon D. Turner; Jerri M. Rook; Craig W. Lindsley; P. Jeffrey Conn; Brad A. Grueter, Neuropsychopharmacology, 2018

Glutamatergic transmission in the nucleus accumbens shell (NAcSh) is a substrate for reward learning and motivation. Metabotropic glutamate (mGlu) receptors regulate NAcSh synaptic strength by inducing long-term depression (LTD). Inputs from prefrontal cortex (PFC) and medio-dorsal thalamus (MDT) ...

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ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α deacetylation

13-Mar-2018 | Shuyi Wang; Cong Wang; Subat Turdi; Kacy L. Richmond; Yingmei Zhang; Jun Ren, International Journal of Obesity, 2018

Uncorrected obesity contributes to cardiac remodeling and contractile dysfunction although the underlying mechanism remains poorly understood. Mitochondrial aldehyde dehydrogenase (ALDH2) is a mitochondrial enzyme with some promises in a number of cardiovascular diseases. This study was designed ...

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Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior

05-Mar-2018 | Véronique Deroche-Gamonet; Jean-Michel Revest; Jean-François Fiancette; Eric Balado; Muriel Koehl; Noë ..., Molecular Psychiatry, 2018

The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis ...

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Visualization of Fluorescent Protein Expression in Whole-Mount Postimplantation-Stage Mouse Embryos

01-Mar-2018 | Behringer, R., Gertsenstein, M., Nagy, K. V., Nagy, A., CSH Protocols, 2018

Fluorescent protein (FP)-expressing transgenic mice are powerful genetic resources for marking both live and fixed cells and tissues. Expression in live embryos requires only dissection and visualization using an appropriate microscope. Fixation can compromise FP activity. A simple ...

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Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion

22-Feb-2018 | Jörn Karhausen; Joshua D. Bernstock; Kory R. Johnson; Huaxin Sheng; Qing Ma; Yuntian Shen; Wei Yang; John M. Ha ..., Laboratory Investigation, 2018

The intestinal epithelium constitutes a crucial defense to the potentially life-threatening effects of gut microbiota. However, due to a complex underlying vasculature, hypoperfusion and resultant tissue ischemia pose a particular risk to function and integrity of the epithelium. The small ...

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