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5,398 Newest Publications about the topic toxicity

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Going on offense against the gram-negative defense [Microbiology]

26-Jun-2018 | Bryon S. Drown; Paul J. Hergenrother, Proceedings of the National Academy of Sciences current issue, 2018

Bacterial infections resistant to antibiotics are becoming more common, posing a significant health risk (1). The CDC and WHO have identified gram-negative drug-resistant pathogens as being particularly dangerous, and such infections are resistant to nearly all available antibiotics in some cases ...

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Combinatorial drug discovery in nanoliter droplets [Engineering]

26-Jun-2018 | Anthony Kulesa; Jared Kehe; Juan E. Hurtado; Prianca Tawde; Paul C. Blainey, Proceedings of the National Academy of Sciences current issue, 2018

The conventional single-agent approach to therapeutics is challenged by the redundancy and feedback in biological networks. The use of multiple drugs in combination might improve desired functional outcomes while reducing toxicity and overcoming drug resistance. However, the complexity and ...

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Resolution and evaluation of 3-chlorophenyl-3-hydroxypropionylhydroxamic acid as antivirulence agent with excellent eradication efficacy in Helicobacter pylori infected mice

24-Jun-2018 | Author(s): Qi Liu, Wei-Wei Ni, Zhen Li, Cai-Fu Bai, Dan-Dan Tan, Chang-Jun Pu, Dong Zhou, Qing-Peng ..., European Journal of Pharmaceutical Science, 2018

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Qi Liu, Wei-Wei Ni, Zhen Li, Cai-Fu Bai, Dan-Dan Tan, Chang-Jun Pu, Dong Zhou, Qing-Peng Tian, Ni Luo, Kai-Li Tan, Le Dai, Yuan Yan, Yong Pei, Xian-Hui Li, ...

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Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

24-Jun-2018 | Author(s): Jaismy Jacob P, S.L. Manju, K.R. Ethiraj, Geetha Elias, European Journal of Pharmaceutical Science, 2018

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Jaismy Jacob P, S.L. Manju, K.R. Ethiraj, Geetha Elias Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and lipoxygenase (LOX) pathways are ...

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Identification of new drug-like compounds from millets as Xanthine oxidoreductase inhibitors for treatment of Hyperuricemia: A molecular docking and simulation study

17-Jun-2018 | Author(s): Rajesh Kumar Pathak, Ayushi Gupta, Rohit Shukla, Mamta Baunthiyal, Computational Biology and Chemistry, 2018

Publication date: October 2018 Source:Computational Biology and Chemistry, Volume 76 Author(s): Rajesh Kumar Pathak, Ayushi Gupta, Rohit Shukla, Mamta Baunthiyal Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation during purine catabolism. ...

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Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice

17-Jun-2018 | Author(s): Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Nataša Škalko-Basnet, Johan Isaksson, Puru ..., European Journal of Pharmaceutical Science, 2018

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Nataša Škalko-Basnet, Johan Isaksson, Purusotam Basnet, Ann Mari Holsæter The increased prevalence of chronic wounds ...

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A MFS-like plasma membrane transporter required for Leishmania virulence protects the parasites from iron toxicity

15-Jun-2018 | Maria Fernanda Laranjeira-Silva; Wanpeng Wang; Tamika K. Samuel; Fernando Y. Maeda; Vladimir Michailowsky; Iqbal Ham ..., PLoS Pathogens, 2018

by Maria Fernanda Laranjeira-Silva, Wanpeng Wang, Tamika K. Samuel, Fernando Y. Maeda, Vladimir Michailowsky, Iqbal Hamza, Zhongchi Liu, Norma W. Andrews Iron is essential for many cellular processes, but can generate highly toxic hydroxyl radicals in the presence of oxygen. Therefore, ...

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Energies, Vol. 11, Pages 1582: Influence of Hydrothermal Carbonization on Composition, Formation and Elimination of Biphenyls, Dioxins and Furans in Sewage Sludge

15-Jun-2018 | Brookman, Heiner ; Gievers, Fabian ; Zelinski, Volker ; Ohlert, Jan ; Loewen, Achim, Energies, 2018

Energies, Vol. 11, Pages 1582: Influence of Hydrothermal Carbonization on Composition, Formation and Elimination of Biphenyls, Dioxins and Furans in Sewage Sludge Energies doi: 10.3390/en11061582 Authors: Heiner Brookman Fabian Gievers Volker Zelinski Jan Ohlert Achim ...

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Effects of low dose silver nanoparticle treatment on the structure and community composition of bacterial freshwater biofilms

14-Jun-2018 | Alexandra Y. Grün; Constantin B. App; Andreas Breidenbach; Jutta Meier; George Metreveli; Gabriele E. Schaumann; Wer ..., PLoS ONE, 2018

by Alexandra Y. Grün, Constantin B. App, Andreas Breidenbach, Jutta Meier, George Metreveli, Gabriele E. Schaumann, Werner Manz The application of engineered silver nanoparticles (AgNPs) in a considerable amount of registered commercial products inevitably will result in the continuous release ...

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Computer-aided drug design and virtual screening of targeted combinatorial libraries of mixed-ligand transition metal complexes of 2-butanone thiosemicarbazone

10-Jun-2018 | Author(s): Tahmeena Khan, Rumana Ahmad, Iqbal Azad, Saman Raza, Seema Joshi, Abdul Rahman Khan, Computational Biology and Chemistry, 2018

Publication date: August 2018 Source:Computational Biology and Chemistry, Volume 75 Author(s): Tahmeena Khan, Rumana Ahmad, Iqbal Azad, Saman Raza, Seema Joshi, Abdul Rahman Khan The present paper deals with in silico evaluation of 32 virtually designed transition metal ...

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