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98 Newest Publications about the topic theophylline

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Development and applications of a physiologically-based model of paediatric oral drug absorption

21-Mar-2018 | Author(s): T.N. Johnson, J.J. Bonner, G.T. Tucker, D.B. Turner, M. Jamei, European Journal of Pharmaceutical Science, 2018

Publication date: 30 March 2018 Source:European Journal of Pharmaceutical Sciences, Volume 115 Author(s): T.N. Johnson, J.J. Bonner, G.T. Tucker, D.B. Turner, M. Jamei There is increasing interest in paediatric drug absorption and the development of biopharmaceutics tools to ...

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Development and applications of a physiologically-based model of paediatric oral drug absorption

21-Mar-2018 | Author(s): T.N. Johnson, J.J. Bonner, G.T. Tucker, D.B. Turner, M. Jamei, European Journal of Pharmaceutical Science, 2018

Publication date: 30 March 2018 Source:European Journal of Pharmaceutical Sciences, Volume 115 Author(s): T.N. Johnson, J.J. Bonner, G.T. Tucker, D.B. Turner, M. Jamei There is increasing interest in paediatric drug absorption and the development of biopharmaceutics tools to ...

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Functional characterization and tissue expression of marmoset cytochrome P450 2E1

05-May-2017 | Shotaro Uehara, Yasuhiro Uno, Etsuko Tomioka, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki, Biopharmaceutics & Drug Disposition, 2017

Abstract Common marmosets (Callithrix jacchus) have attracted increasing attention as a useful small non‐human primate model in preclinical research. However, studies on marmoset cytochrome P450 (P450) 2E enzyme have scarcely been conducted. In this study, the full‐length cDNA encoding P450 ...

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Development and characterization of new functionalized polyurethanes for sustained and site-specific drug release in the gastrointestinal tract

19-Feb-2017 | Author(s): María Dolores Campiñez, Elena Benito, Lucía Romero-Azogil, Ángela Aguilar-de-Leyva, María de Grac ..., European Journal of Pharmaceutical Science, 2017

Publication date: 30 March 2017 Source:European Journal of Pharmaceutical Sciences, Volume 100 Author(s): María Dolores Campiñez, Elena Benito, Lucía Romero-Azogil, Ángela Aguilar-de-Leyva, María de Gracia García-Martín, Juan Antonio Galbis, Isidoro Caraballo The main ...

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Health benefits of methylxanthines in neurodegenerative diseases

11-Jan-2017 | Ainhoa Oñatibia‐Astibia, Rafael Franco, Eva Martínez‐Pinilla, Molecular Nutrition & Food Research, 2017

Methylxanthines (MTXs) are consumed by almost everybody in almost every area of the world. Caffeine, theophylline and theobromine are the most well‐known members of this family of compounds; they are present, inter alia, in coffee, tea, cacao, yerba mate and cola drinks. MTXs are readily ...

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Drug-drug cocrystals of antituberculous 4-aminosalicylic acid: Screening, crystal structures, thermochemical and solubility studies

08-Jan-2017 | Author(s): Ksenia V. Drozd, Alex N. Manin, Andrei V. Churakov, German L. Perlovich, European Journal of Pharmaceutical Science, 2017

Publication date: 1 March 2017 Source:European Journal of Pharmaceutical Sciences, Volume 99 Author(s): Ksenia V. Drozd, Alex N. Manin, Andrei V. Churakov, German L. Perlovich Experimental multistage cocrystal screening of the antituberculous drug 4-aminosalicylic acid (PASA) has ...

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Prediction of serum theophylline concentrations and CYP1A2 activity by analyzing urinary metabolites in preterm infants

20-Dec-2016 | Jin A. Sohn, Han‐Suk Kim, Jaeseong Oh, Joo‐Youn Cho, Kyung‐Sang Yu, Juyoung Lee, Seung Han Shin, Jin A. Lee, Chang W ..., British Journal of Clinical Pharmacology, 2016

Aims The purpose of this study was to explore clinical markers reflecting developmental changes in drug clearance by preterm infants. Methods Preterm infants administered aminophylline or theophylline to treat apnoea of prematurity were enrolled in this study. Trough and one of 2 h, 4 h ...

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Applicability of a computational design approach for synthetic riboswitches

19-Dec-2016 | Domin G, Findeiß S, Wachsmuth M, et al., Nucleic Acids Research, 2016

AbstractRiboswitches have gained attention as tools for synthetic biology, since they enable researchers to reprogram cells to sense and respond to exogenous molecules. In vitro evolutionary approaches produced numerous RNA aptamers that bind such small ligands, but their conversion into ...

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Measurement of caffeine and its three primary metabolites in human plasma by HPLC‐ESI‐MS/MS and clinical application

19-Nov-2016 | Feng Chen, Zhe‐Yi Hu, Robert B. Parker, S. Casey Laizure, Biomedical Chromatography, 2016

Abstract Caffeine is a mild stimulant with significant potential for abuse being consumed in larger doses with the widespread availability of energy drinks and by novel routes of administration such as inspired powder, oral sprays, and electronic cigarettes. How these recent changes in ...

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Captagon: use and trade in the Middle East

21-Oct-2016 | Ahmed AL‐Imam, Rita Santacroce, Andres Roman‐Urrestarazu, Robert Chilcott, Giuseppe Bersani, Giovanni Martinotti, Or ..., Human Psychopharmacology: Clinical and Experimental, 2016

Abstract Background Fenetheylline, a psychostimulant drug, often branded as Captagon, is a combination of amphetamine and theophylline. Since the cessation of its legal production in 1986, counterfeited products have been produced illicitly in south‐east Europe and far‐east Asia. Its ...

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