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292 Newest Publications about the topic structural biology


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Tackling microtubule-tau interactions

15-Jun-2018 | Stella Hurtley; Stella M. Hurtley, Science , 2018

Structural Biology Alzheimer's disease is a major cause of death in the elderly. Disease progression is associated with the accumulation of neurofibrillary tangles composed of tau, a protein important for neuronal development and function. Tangle formation is preceded by phosphorylation events ...


Edge cases cause trouble

15-Jun-2018 | Caroline Ash; Jesse Smith; Michael A. Funk, Science , 2018

Structural Biology Single-particle cryo–electron microscopy detects macromolecules trapped in a thin layer of vitreous ice. High-resolution, accurate reconstructions benefit from randomly arranged and well-dispersed particles, but biological samples do not always cooperate. Noble et al. used cryo


Ultrafast nonthermal heating of water initiated by an X-ray Free-Electron Laser [Biophysics and Computational Biology]

29-May-2018 | Kenneth R. Beyerlein; H. Olof Jönsson; Roberto Alonso-Mori; Andrew Aquila; Saša Bajt; Anton Barty; Richard Bean; Jas ..., Proceedings of the National Academy of Sciences current issue, 2018

X-ray Free-Electron Lasers have opened the door to a new era in structural biology, enabling imaging of biomolecules and dynamics that were impossible to access with conventional methods. A vast majority of imaging experiments, including Serial Femtosecond Crystallography, use a liquid jet to ...


Structural biology: cisTEM software for cryo-EM

27-Apr-2018 | Nature Methods, 2018

Structural biology: cisTEM software for cryo-EM Structural biology: cisTEM software for cryo-EM, Published online: 27 April 2018; doi:10.1038/nmeth.4672 Structural biology: cisTEM software for cryo-EM


Recognizing centromere by kinetochore

19-Jan-2018 | Stella Hurtley; Steve Mao, Science , 2018

Structural Biology The kinetochore proteins CENP-N and CENP-C recognize the histone H3 variant CENP-A in the centromeric nucleosome. This ensures proper kinetochore assembly and accurate segregation of chromosomes. Chittori et al. describe the cryo-electron microscopy structure of the human CENP-A


Toward dynamic structural biology: Two decades of single-molecule Förster resonance energy transfer

19-Jan-2018 | Eitan Lerner; Thorben Cordes; Antonino Ingargiola; Yazan Alhadid; SangYoon Chung; Xavier Michalet; Shimon Weiss, Science , 2018

Classical structural biology can only provide static snapshots of biomacromolecules. Single-molecule Förster resonance energy transfer (smFRET) paved the way for studying dynamics in macromolecular structures under biologically relevant conditions. Since its first implementation in 1996, smFRET ...


Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies

11-Jan-2018 | Mingyue Zheng, Jihui Zhao, Chen Cui, Zunyun Fu, Xutong Li, Xiaohong Liu, Xiaoyu Ding, Xiaoqin Tan, Fei Li, Xiaomin L ..., Medicinal Research Reviews, 2018

Abstract Over the past quarter of a century, there has been rapid development in structural biology, which now can provide solid evidence for understanding the functions of proteins. Concurrently, computational approaches with particular relevance to the chemical biology and drug design (CBDD) ...


A source of methane in the upper ocean

08-Dec-2017 | Stella Hurtley; Valda Vinson, Science , 2017

Structural Biology Methane concentrations are high in oxygenated surface waters. Methylphosphonate (MPn) is a suggested source, but an enzyme that synthesizes Mpn (MPnS) has so far only been identified in one ocean microbe, albeit an abundant one: the archaeon Nitrosopumilus maritimus . Born et ...


Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components

06-Dec-2017 | Luvena L. Ong; Nikita Hanikel; Omar K. Yaghi; Casey Grun; Maximilian T. Strauss; Patrick Bron; Josephine Lai-Kee-Him ..., Nature, 2017

Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components Nature 552, 7683 (2017). doi:10.1038/nature24648 Authors: Luvena L. Ong, Nikita Hanikel, Omar K. Yaghi, Casey Grun, Maximilian T. Strauss, Patrick ...


Holding a master regulator in check

01-Dec-2017 | Stella Hurtley; Valda Vinson, Science , 2017

Structural Biology A family of eukaryotic protein kinases, the phosphatidylinositol 3-kinase-related kinases (PIKKs), has key functions in DNA repair and nutrient sensing. In humans, ATR kinase locates DNA damage through its partner, ATRIP. Once activated, ATR initiates a cell-cycle cascade that


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