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278 Newest Publications about the topic spectrometers

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Mid-infrared frequency comb via coherent dispersive wave generation in silicon nitride nanophotonic waveguides

16-Apr-2018 | Hairun Guo; Clemens Herkommer; Adrien Billat; Davide Grassani; Chuankun Zhang; Martin H. P. Pfeiffer; Wenle Weng; Ca ..., Nature Photonics, 2018

Mid-infrared optical frequency combs are of significant interest for molecular spectroscopy due to the large absorption of molecular vibrational modes on the one hand, and the ability to implement superior comb-based spectroscopic modalities with increased speed, sensitivity and precision on the ...

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Proteomics Insights into Autophagy

20-Oct-2017 | Emmanuel K Cudjoe, Tareq Saleh, Adam Hawkridge, David A Gewirtz; Emmanuel K. Cudjoe, Tareq Saleh, Adam M. Hawkridge, ..., PROTEOMICS, 2017

Autophagy, a conserved cellular process by which cells recycle their contents either to maintain basal homeostasis or in response to external stimuli, has for the past two decades become one of the most studied physiological processes in cell biology. The 2016 Nobel Prize in Medicine and Biology ...

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The Encyclopedia of Proteome Dynamics: a big data ecosystem for (prote)omics

07-Sep-2017 | Brenes A, Afzal V, Kent R, et al., Nucleic Acids Research, 2017

Abstract Driven by improvements in speed and resolution of mass spectrometers (MS), the field of proteomics, which involves the large-scale detection and analysis of proteins in cells, tissues and organisms, continues to expand in scale and complexity. There is a resulting growth in datasets of ...

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PROCAL: A set of 40 peptide standards for retention time indexing, column performance monitoring and collision energy calibration

05-Sep-2017 | Daniel Paul Zolg, Mathias Wilhelm, Peng Yu, Tobias Knaute, Johannes Zerweck, Holger Wenschuh, Ulf Reimer, Karsten Sc ..., PROTEOMICS, 2017

Beyond specific applications such as the relative or absolute quantification of peptides in targeted proteomic experiments, synthetic spike‐in peptides are not yet systematically used as internal standards in bottom‐up proteomics. A number of retention time standards have been reported that ...

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Optimizing High-Resolution Mass Spectrometry for the Identification of Low-Abundance Post-Translational Modifications of Intact Proteins

08-Aug-2017 | Lisa E. Kilpatrick; Eric L. Kilpatrick, Journal of Proteome Research, 2017

Intact protein analysis by liquid chromatography–mass spectrometry (LC-MS) is now possible due to the improved capabilities of mass spectrometers yielding greater resolution, mass accuracy, and extended mass ranges. Concurrent measurement of post-translational modifications (PTMs) during LC-MS of ...

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SpecOMS: A Full Open Modification Search Method Performing All-to-All Spectra Comparisons within Minutes

11-Jul-2017 | Matthieu David; Guillaume Fertin; Hélène Rogniaux; Dominique Tessier, Journal of Proteome Research, 2017

The analysis of discovery proteomics experiments relies on algorithms that identify peptides from their tandem mass spectra. The almost exhaustive interpretation of these spectra remains an unresolved issue. At present, an important number of missing interpretations is probably due to peptides ...

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multiplierz v2.0: a Python‐based ecosystem for shared access and analysis of native mass spectrometry data

07-Jul-2017 | William M. Alexander, Scott B. Ficarro, Guillaume Adelmant, Jarrod A. Marto, PROTEOMICS, 2017

The continued evolution of modern mass spectrometry instrumentation and associated methods represents a critical component in efforts to decipher the molecular mechanisms which underlie normal physiology and understand how dysregulation of biological pathways contributes to human disease. The ...

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P4P: a peptidome-based strain-level genome comparison web tool

08-May-2017 | Blanco-Míguez A, Fdez-Riverola F, Lourenço A, et al., Nucleic Acids Research, 2017

Abstract Peptidome similarity analysis enables researchers to gain insights into differential peptide profiles, providing a robust tool to discriminate strain-specific peptides, true intra-species differences among biological replicates or even microorganism-phenotype variations. However, no in ...

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From single cells to our planet—recent advances in using mass spectrometry for spatially resolved metabolomics

15-Jan-2017 | Author(s): Daniel Petras, Alan K Jarmusch, Pieter C Dorrestein, Current Opinion in Chemical Biology, 2017

Publication date: February 2017 Source:Current Opinion in Chemical Biology, Volume 36 Author(s): Daniel Petras, Alan K Jarmusch, Pieter C Dorrestein Spatial information in the form of 3D digital content has been increasingly integrated into our daily lives. Metabolomic studies ...

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Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

02-Dec-2016 | Luca Fornelli; Kenneth R. Durbin; Ryan T. Fellers; Bryan P. Early; Joseph B. Greer; Richard D. LeDuc; Philip D. Comp ..., Journal of Proteome Research, 2016

Over the past decade, developments in high resolution mass spectrometry have enabled the high throughput analysis of intact proteins from complex proteomes, leading to the identification of thousands of proteoforms. Several previous reports on top-down proteomics (TDP) relied on hybrid ion ...

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