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79 Newest Publications about the topic proteasomes


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Context memory formation requires activity-dependent protein degradation in the hippocampus [RESEARCH]

01-Nov-2017 | Patrick K. Cullen; Nicole C. Ferrara; Shane E. Pullins; Fred J. Helmstetter, Learning & Memory, 2017

Numerous studies have indicated that the consolidation of contextual fear memories supported by an aversive outcome like footshock requires de novo protein synthesis as well as protein degradation mediated by the ubiquitin–proteasome system (UPS). Context memory formed in the absence of an ...


In situ structural studies of tripeptidyl peptidase II (TPPII) reveal spatial association with proteasomes [Biophysics and Computational Biology]

25-Apr-2017 | Yoshiyuki Fukuda; Florian Beck; Jürgen M. Plitzko; Wolfgang Baumeister, Proceedings of the National Academy of Sciences current issue, 2017

Tripeptidyl peptidase II (TPPII) is a eukaryotic protease acting downstream of the 26S proteasome; it removes tripeptides from the degradation products released by the proteasome. Structural studies in vitro have revealed the basic architecture of TPPII, a two-stranded linear polymer that ...


Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c [Biochemistry]

25-Apr-2017 | Chueh-Ling Kuo; Alfred Lewis Goldberg, Proceedings of the National Academy of Sciences current issue, 2017

In mammalian cells, the 26S proteasomes vary in composition. In addition to the standard 28 subunits in the 20S core particle and 19 subunits in each 19S regulatory particle, a small fraction (about 10–20% in our preparations) also contains the deubiquitinating enzyme Usp14/Ubp6, which regulates ...


[This Week in Science] Proteasomes and SUMO wrestle chromosomes

27-Jan-2017 | Guy Riddihough, Science , 2017

Cell Division Meiosis is the double cell division that generates haploid gametes from diploid parental cells. Pairing of homologous chromosomes during the first meiotic division ensures that each gamete receives a complete set of chromosomes. The proteasome, on the other hand, is a molecular ...


[Report] A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination

27-Jan-2017 | H. B. D. Prasada Rao; Huanyu Qiao; Shubhang K. Bhatt; Logan R. J. Bailey; Hung D. Tran; Sarah L. Bourne; Wendy Qiu; ..., Science , 2017

Meiosis produces haploid gametes through a succession of chromosomal events, including pairing, synapsis, and recombination. Mechanisms that orchestrate these events remain poorly understood. We found that the SUMO (small ubiquitin-like modifier)–modification and ubiquitin-proteasome systems ...


Subunit‐selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections

24-Jan-2017 | Johana C. Misas‐Villamil, Aranka M van der Burgh, Friederike Grosse‐Holz, Marcel Bach‐Pages, Judit Kovács, Farnusch ..., The Plant Journal, 2017

Summary The proteasome is a nuclear ‐ cytoplasmic proteolytic complex involved in nearly all regulatory pathways in plant cells. The three different catalytic activities of the proteasome can have different functions but tools to monitor and control these subunits selectively are not yet ...


Gyre and gimble in the proteasome [Biochemistry]

15-Nov-2016 | Mark Hochstrasser, Proceedings of the National Academy of Sciences current issue, 2016

Large, multisubunit machines carry out many fundamental biochemical processes in eukaryotic cells. Examples include the spliceosomes that remove introns from mRNA precursors, ribosomes that synthesize proteins, and proteasomes that degrade intracellular proteins. Most such machines use ordered ...


Exploring the Binding Affinity of Novel Syringic Acid Analogues and Critical Determinants of Selectivity as Potent Proteasome Inhibitors

12-Oct-2016 | Cheemanapalli, Srinivasulu; M. Anuradha, C.; Madhusudhana, P.; Mahesh, M.; B. Raghavendra, Pongali; S. Kumar, Chitta, Anti-Cancer Agents in Medicinal Chemistry , 2016

Abstract: Syringic acid, a known plant phenolic compound and its analogues are known to possess high proteasome inhibitory activity. In the current work, we describe synthesis, characterization, DFT, docking of syringic acid (SA) and analogues (SAA1 and SAA2) and biological effects were ...


The Ubiquitin-like Protein FAT10 Stabilizes eEF1A1 Expression to Promote Tumor Proliferation in a Complex Manner

15-Aug-2016 | Xiuxia Liu; Leifeng Chen; Jin Ge; Chen Yan; Zixi Huang; Junwen Hu; Chongyu Wen; Ming Li; Da Huang; Yumin Qiu; Haibin ..., Cancer Research, 2016

Human HLA-F adjacent transcript 10 (FAT10) is the only ubiquitin-like protein that can directly target substrates for degradation by proteasomes, but it can also stabilize the expression of certain substrates by antagonizing ubiquitination, through mechanisms as yet uncharacterized. In this ...


CD8+ T cells of Listeria monocytogenes‐infected mice recognize both linear and spliced proteasome products

23-Feb-2016 | Anouk C.M. Platteel, Michele Mishto, Kathrin Textoris‐Taube, Christin Keller, Juliane Liepe, Dirk H. Busch, Peter M. ..., European Journal of Immunology, 2016

Abstract CD8+ T cells responding to infection recognize pathogen‐derived epitopes presented by MHC class‐I molecules. While most of such epitopes are generated by proteasome‐mediated antigen cleavage, analysis of tumor antigen processing has revealed that epitopes may also derive from ...


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