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388 Newest Publications about the topic protease inhibitors

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Anti-haemostatic compounds from the vampire snail Cumia reticulata: Molecular cloning and in-silico structure-function analysis

27-May-2018 | Author(s): Maria Vittoria Modica, Jonathan Reinoso Sánchez, Andrea Pasquadibisceglie, Marco Oliverio, Paolo ..., Computational Biology and Chemistry, 2018

Publication date: August 2018 Source:Computational Biology and Chemistry, Volume 75 Author(s): Maria Vittoria Modica, Jonathan Reinoso Sánchez, Andrea Pasquadibisceglie, Marco Oliverio, Paolo Mariottini, Manuela Cervelli Blood-feeding animals are known for their ability to ...

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Deep recurrent neural networks in HIV-1 protease cleavage classification

28-Apr-2018 | Nima Shayanfar; Vali Derhami; Mehdi Rezaeian, International Journal of Data Mining and Bioinformatics, 2018

Deep recurrent neural networks in HIV-1 protease cleavage classificationNima Shayanfar; Vali Derhami; Mehdi RezaeianInternational Journal of Data Mining and Bioinformatics, Vol. 19, No. 4 (2017) pp. 298 - 311Many of the drugs that are used by HIV infected humans can be catalogued as protease ...

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Synthetic fermentation of bioactive molecules

15-Apr-2018 | Author(s): Iain A Stepek, Jeffrey W Bode, Current Opinion in Chemical Biology, 2018

Publication date: October 2018 Source:Current Opinion in Chemical Biology, Volume 46 Author(s): Iain A Stepek, Jeffrey W Bode The concept of synthetic fermentation is to ‘grow’ complex organic molecules in a controlled and predictable manner by combining small molecule building blocks ...

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Viruses, Vol. 10, Pages 190: Counteracting Akt Activation by HIV Protease Inhibitors in Monocytes/Macrophages

13-Apr-2018 | Pasquereau, Sébastien ; Kumar, Amit ; Abbas, Wasim ; Herbein, Georges, Viruses, 2018

Viruses, Vol. 10, Pages 190: Counteracting Akt Activation by HIV Protease Inhibitors in Monocytes/Macrophages Viruses doi: 10.3390/v10040190 Authors: Sébastien Pasquereau Amit Kumar Wasim Abbas Georges Herbein Akt signaling plays a central role in many biological processes ...

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Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

27-Oct-2017 | Armiyaw S. Nasamu; Svetlana Glushakova; Ilaria Russo; Barbara Vaupel; Anna Oksman; Arthur S. Kim; Daved H. Fremont; ..., Science , 2017

Sweats and fever are the hallmarks of malaria. Red blood cells are the replication factories for malaria parasites. Fever occurs when the parasites' merozoite stages burst en masse from red blood cells into the circulation. Nasamu et al. and Pino et al. discovered that two parasite proteases, ...

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A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress

27-Oct-2017 | Paco Pino; Reto Caldelari; Budhaditya Mukherjee; Juha Vahokoski; Natacha Klages; Bohumil Maco; Christine R. Collins; ..., Science , 2017

Sweats and fever are the hallmarks of malaria. Red blood cells are the replication factories for malaria parasites. Fever occurs when the parasites' merozoite stages burst en masse from red blood cells into the circulation. Nasamu et al. and Pino et al. discovered that two parasite proteases, ...

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A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress

27-Oct-2017 | Paco Pino; Reto Caldelari; Budhaditya Mukherjee; Juha Vahokoski; Natacha Klages; Bohumil Maco; Christine R. Collins; ..., Science , 2017

Sweats and fever are the hallmarks of malaria. Red blood cells are the replication factories for malaria parasites. Fever occurs when the parasites' merozoite stages burst en masse from red blood cells into the circulation. Nasamu et al. and Pino et al. discovered that two parasite proteases, ...

more

TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

30-Aug-2017 | Peter Thornton, Jean Sevalle, Mike J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seem ..., EMBO Molecular Medicine, 2017

Abstract We have characterised the proteolytic cleavage events responsible for the shedding of triggering receptor expressed on myeloid cells 2 (TREM2) from primary cultures of human macrophages, murine microglia and TREM2‐expressing human embryonic kidney (HEK293) cells. In all cell types, a ...

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NaMYB8 regulates distinct, optimally distributed herbivore defense traits

26-Aug-2017 | Martin Schäfer, Christoph Brütting, Shuqing Xu, Zhihao Ling, Anke Steppuhn, Ian T. Baldwin, Meredith C. Schuman, Journal of Integrative Plant Biology, 2017

Summary When herbivores attack, plants specifically reconfigure their metabolism. Herbivory on the wild tobacco Nicotiana attenuata strongly induces the R2/R3 MYB transcriptional activator MYB8, which was reported to specifically regulate the accumulation of phenolamides (PAs). We discovered ...

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CHARACTERIZATION OF CLINICAL PREDICTORS OF NATURALLY OCCURRING NS3/NS4A PROTEASE POLYMORPHISM IN GENOTYPE 1 HEPATITIS C VIRUS MONO AND HIV CO‐INFECTED PATIENTS

12-Jul-2017 | Gaspar Lisboa Neto, Fernanda M Malta, Michele S Gomes‐Gouvêa, Caroline F Noble, Camila Malta Romano, João Renato R P ..., Journal of Medical Virology, 2017

Summary Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co‐infected patients. ...

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