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189 Newest Publications about the topic preeclampsia


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Transcriptional signature of the decidua in preeclampsia [Biological Sciences]

12-Jun-2018 | Ji-Long Liu; Wen-Qian Zhang; Ming-Yu Huang, Proceedings of the National Academy of Sciences current issue, 2018

An emerging concept is that the genesis of preeclampsia is rooted in dysregulated decidualization (1). In PNAS, Garrido-Gomez et al. (2) demonstrate a distinct transcriptional signature in the endometrial stromal cells (ESCs) of preeclampsia patients compared with control cells during in vitro ...


Statistical and artificial neural network-based analysis to understand complexity and heterogeneity in preeclampsia

03-Jun-2018 | Author(s): T. Murlidharan Nair, Computational Biology and Chemistry, 2018

Publication date: August 2018 Source:Computational Biology and Chemistry, Volume 75 Author(s): T. Murlidharan Nair Preeclampsia is a pregnancy associated disease. It is characterized by high blood pressure and symptoms that are indicative of damage to other organ systems, most often ...


The inhibitory effect of BKCa channels induced by autoantibodies against angiotensin II type 1 receptor is independent of AT1R

25-Apr-2018 | Wang P, Zhang S, Ren J, et al., Acta Biochimica et Biophysica Sinica, 2018

Abstract Autoantibodies against angiotensin II Type 1 receptor (AT1-AA) are routinely detected in the serum of preeclampsia patients, which results in an increase in vascular tone and an elevation in intracellular calcium concentration of rat vascular smooth muscle (VSM). The big conductance ...


Decreased expression of JHDMID in placenta is associated with preeclampsia through HLA-G

06-Apr-2018 | Shouling Luo; Jiangnan Pei; Xiaotian Li; Weirong Gu, Journal of Human Hypertension, 2018

The exact mechanism of preeclampsia (PE) remains unclear, accumulating researches have indicated multiple epigenetic factors relate to PE and histone methylation plays a crucial role in modifying the gene expression. So we aimed to confirm that abnormal expression of histone demethylase JHDM1D ...


Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology [Medical Sciences]

03-Oct-2017 | Tamara Garrido-Gomez; Francisco Dominguez; Alicia Quiñonero; Patricia Diaz-Gimeno; Mirhan Kapidzic; Matthew Gormley; ..., Proceedings of the National Academy of Sciences current issue, 2017

In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta’s role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial ...


Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics [Medical Sciences]

12-Sep-2017 | Jason C. H. Tsang; Joaquim S. L. Vong; Lu Ji; Liona C. Y. Poon; Peiyong Jiang; Kathy O. Lui; Yun-Bi Ni; Ka Fai To; Y ..., Proceedings of the National Academy of Sciences current issue, 2017

The human placenta is a dynamic and heterogeneous organ critical in the establishment of the fetomaternal interface and the maintenance of gestational well-being. It is also the major source of cell-free fetal nucleic acids in the maternal circulation. Placental dysfunction contributes to ...


Circulating peptide prevents preeclampsia

18-Aug-2017 | Robert C. Wirka; Thomas Quertermous, Science , 2017

Preeclampsia (PE) is a devastating complication of pregnancy that puts both mother and child at risk for clinical complications. In severe cases, PE can progress to multi-organ dysfunction and death. Characterized by hypertension (high blood pressure) and proteinuria (protein in the urine), the ...


ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice

18-Aug-2017 | Lena Ho; Marie van Dijk; Sam Tan Jian Chye; Daniel M. Messerschmidt; Serene C. Chng; Sheena Ong; Ling Ka Yi; Souad B ..., Science , 2017

Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin ...


Modeling a pregnancy disorder

18-Aug-2017 | Priscilla N. Kelly, Science , 2017

Pregnancy![Figure][1] Preeclampsia in pregnancy is dangerous for mother and child. PHOTO: BY MIKUMISTOCK/SHUTTERSTOCK Preeclampsia, a dangerous pregnancy disorder marked by high blood pressure, can lead to premature birth and be life-threatening to the mother and baby. Research leading to


The pregnancy in neurofibromatosis 1: A retrospective register‐based total population study

16-Aug-2017 | Jussi Leppävirta, Roope A. Kallionpää, Elina Uusitalo, Tero Vahlberg, Minna Pöyhönen, Susanna Timonen, Juha Peltonen ..., American Journal of Medical Genetics Part A, 2017

The objective of this retrospective total population study was to form a view of the pregnancies of the patients with neurofibromatosis type 1 (NF1). A cohort of 1,410 Finnish patients with NF1 was acquired by searching NF1‐related inpatient and outpatient hospital visits and confirming the ...


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