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82 Newest Publications about the topic pioglitazone

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Effects of combination of mitiglinide with various oral antidiabetic drugs in streptozotocin‐nicotinamide‐induced type 2 diabetic rats and Zucker fatty rats

26-Jul-2017 | Kenji Akahane, Kazuma Ojima, Ayaka Yokoyama, Toshihiro Inoue, Sumiyoshi Kiguchi, Satoshi Tatemichi, Hiroo Takeda, Yo ..., Clinical and Experimental Pharmacology and Physiology, 2017

Abstract We examined the effects of combining the rapid insulin secretagogue, mitiglinide, with various oral hypoglycemic drugs including biguanides, pioglitazone, α‐glucosidase inhibitors, and sodium‐glucose co‐transporter 2 inhibitors in a rat model of type 2 diabetes. The oral glucose ...

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Potential of telmisartan in the treatment of benign prostatic hyperplasia

20-Jul-2017 | Ismail Ogunbayode Ishola, Charles C. Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U. Udokwu, Fundamental & Clinical Pharmacology, 2017

Abstract Benign prostatic hyperplasia (BPH) is a common health problem in aging men. This study was carried out to investigate the protective effect of telmisartan on testosterone induced‐BPH in rats. Fifty‐four male Wistar rats (200 ‐ 250g) were randomly divided into 9 groups (n =6) and ...

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Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus

14-Jul-2017 | Yao Wang; Bo Yu; Li Wang; Ming Yang; Zhiyin Xia; Wei Wei; Fengyu Zhang; Xiaochen Yuan, PLoS ONE, 2017

by Yao Wang, Bo Yu, Li Wang, Ming Yang, Zhiyin Xia, Wei Wei, Fengyu Zhang, Xiaochen Yuan Objective The NLRP3 inflammasome plays an important role in the pathogenesis of inflammation in diabetic nephropathy (DN). Pioglitazone (PIO) has been found to exert an anti-inflammatory effect in patients ...

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Atorvastatin attenuates testosterone induced benign prostatic hyperplasia in rats: role of peroxisome proliferator activated receptor‐γ and cyclo‐oxygenase‐2

21-Jun-2017 | Ismail O. Ishola, Habeeb K. Tijani, Olufunke O. Dosumu, Charles C. Anunobi, Tolulope O. Oshodi, Fundamental & Clinical Pharmacology, 2017

Abstract Diabetes and obesity have been reported to alter sex steroid hormone metabolism. In this study, an attempt was made to investigate the protective effect of atorvastatin (ATR) in combination with celecoxib (CEL) or pioglitazone (PIO) on testosterone‐induced BPH in rats.Male Wistar ...

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The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism

09-Jun-2017 | Patrick A. Vigueira, Kyle S. McCommis, Wesley T. Hodges, George G. Schweitzer, Serena L. Cole, Lalita Oonthonpan, Er ..., Experimental Physiology, 2017

Abstract Rosiglitazone and pioglitazone are thiazolidinedione (TZD) compounds that have been used clinically as insulin‐sensitizing drugs and are generally believed to mediate their effects via activation of the peroxisome proliferator‐activated receptor γ (PPARγ). Recent work has shown that ...

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Identification of tissue‐specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics

27-May-2017 | Jamie L. Barger, James M. Vann, Nicole L. Cray, Thomas D. Pugh, Angela Mastaloudis, Shelly N. Hester, Steven M. Wood ..., Aging Cell, 2017

Summary Caloric restriction (CR) without malnutrition has been shown to retard several aspects of the aging process and to extend lifespan in different species. There is strong interest in the identification of CR mimetics (CRMs), compounds that mimic the beneficial effects of CR on lifespan ...

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Influence of the pharmacokinetic profile on the plasma glucose lowering effect of PPARγ agonist pioglitazone in Wistar fatty rats

11-Mar-2017 | Akihiko Goto, Yoshihiko Tagawa, Yoshiaki Kimura, Akifumi Kogame, Yuu Moriya, Nobuyuki Amano, Biopharmaceutics & Drug Disposition, 2017

Abstract Although the mechanism of action for peroxisome proliferator‐activated receptor gamma (PPARγ) agonists has been extensively explored, the impact of the pharmacokinetic (PK) profile on the pharmacodynamic (PD) effects of PPARγ agonists has not been elucidated in detail. We evaluated ...

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Investigation of Spatial Heterogeneity of Salt Disproportionation in Tablets by Synchrotron X-ray Diffractometry

02-Mar-2017 | Sampada Koranne; Ramprakash Govindarajan; Raj Suryanarayanan, Molecular Pharmaceutics, 2017

Tablets which were binary mixtures of pioglitazone hydrochloride (PioHCl) with magnesium stearate (MgSt), croscarmellose sodium (CCS), microcrystalline cellulose, or lactose monohydrate were prepared. Two sets of experiments, using intact tablets, were performed. (i) Tablets containing PioHCl ...

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Prediction of drug‐induced liver injury using keratinocytes

31-Jan-2017 | Rika Hirashima, Tomoo Itoh, Robert H. Tukey, Ryoichi Fujiwara, Journal of Applied Toxicology, 2017

Abstract Drug‐induced liver injury (DILI) is one of the most common adverse drug reactions. DILI is often accompanied by skin reactions, including rash and pruritus. However, it is still unknown whether DILI‐associated genes such as S100 calcium‐binding protein A and interleukin (IL)‐1β are ...

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Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies

27-Jan-2017 | Stanley Irobekhian Reuben Okoduwa; Ismaila A. Umar; Dorcas B. James; Hajiya M. Inuwa, PLoS ONE, 2017

by Stanley Irobekhian Reuben Okoduwa, Ismaila A. Umar, Dorcas B. James, Hajiya M. Inuwa Background Pathophysiological investigation of disease in a suitable animal model is a classical approach towards development of a credible therapeutic strategy. This study examined appropriate insulin level ...

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