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2,620 Newest Publications about the topic pharmacology

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Proinflammatory enzyme soluble epoxide hydrolase bridges obesity to colonic inflammation and potential carcinogenesis [Pharmacology]

05-Jun-2018 | Guang-Yu Yang, Proceedings of the National Academy of Sciences current issue, 2018

Obesity and chronic inflammation are two well-recognized risk factors for the development of colorectal cancer (CRC). In PNAS, Wang et al. (1) use lipidomic profiling analysis to identify a significant mechanistic link between obesity and colonic inflammation via enhancing the proinflammatory ...

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Viruses, Vol. 10, Pages 293: AIDS Clinical Research in Spain—Large HIV Population, Geniality of Doctors, and Missing Opportunities

30-May-2018 | Soriano, Vicente ; Ramos, José M.; Barreiro, Pablo ; Fernandez-Montero, Jose V., Viruses, 2018

Viruses, Vol. 10, Pages 293: AIDS Clinical Research in Spain—Large HIV Population, Geniality of Doctors, and Missing Opportunities Viruses doi: 10.3390/v10060293 Authors: Vicente Soriano José M. Ramos Pablo Barreiro Jose V. Fernandez-Montero The first cases of AIDS in Spain ...

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Taming unruly chloride channel inhibitors with rational design [Pharmacology]

22-May-2018 | Rebecka J. Sepela; Jon T. Sack, Proceedings of the National Academy of Sciences current issue, 2018

A selective inhibitor is a drug that inhibits the function of one type of protein more than others. This precise block of function can reveal the physiological role of the targeted endogenous protein. In PNAS, Koster et al. (1) describe the design and characterization of inhibitors that ...

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Broad collateral damage of drugs against the gut microbiome

11-May-2018 | Peter Spanogiannopoulos; Peter J. Turnbaugh, Nature Clinical Practice Gastroenterology & Hepatology, 2018

Broad collateral damage of drugs against the gut microbiome Broad collateral damage of drugs against the gut microbiome, Published online: 11 May 2018; doi:10.1038/s41575-018-0028-3 In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target ...

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Pharmaceuticals, Vol. 11, Pages 36: NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2′,2′-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer

23-Apr-2018 | Daifuku, Richard ; Grimes, Sheila ; Stackhouse, Murray, Pharmaceuticals, 2018

Pharmaceuticals, Vol. 11, Pages 36: NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2′,2′-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer Pharmaceuticals doi: 10.3390/ph11020036 Authors: Richard Daifuku Sheila ...

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Circuit dissection of the role of somatostatin in itch and pain

19-Mar-2018 | Jing Huang; Erika Polgár; Hans Jürgen Solinski; Santosh K. Mishra; Pang-Yen Tseng; Noboru Iwagaki; Kieran ..., Nature Neuroscience, 2018

Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the ...

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Marine Drugs, Vol. 16, Pages 72: Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?

22-Feb-2018 | Mattei, César, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 72: Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain? Marine Drugs doi: 10.3390/md16020072 Authors: César Mattei Tetrodotoxin (TTX), the mode of action of which has been known since the 1960s, is widely used in pharmacology as a specific ...

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Marine Drugs, Vol. 16, Pages 68: First Report on Chitin in a Non-Verongiid Marine Demosponge: The Mycale euplectellioides Case

20-Feb-2018 | Żółtowska-Aksamitowska, Sonia ; Shaala, Lamiaa A.; Youssef, Diaa T. A.; Elhady, Sameh S.; Tsurkan, Mikhail V.; P ..., Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 68: First Report on Chitin in a Non-Verongiid Marine Demosponge: The Mycale euplectellioides Case Marine Drugs doi: 10.3390/md16020068 Authors: Sonia Żółtowska-Aksamitowska Lamiaa A. Shaala Diaa T. A. Youssef Sameh S. Elhady Mikhail V. ...

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Making Waves: New Developments in Toxicology With the Zebrafish

19-Feb-2018 | Horzmann K, Freeman J., Toxicological Sciences, 2018

Abstract The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research. The zebrafish model fills a niche between in vitro models and mammalian biomedical models. The developmental characteristics of the small fish are strategically being used by scientists to study ...

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Marine Drugs, Vol. 16, Pages 55: Seaweed Bioactive Compounds against Pathogens and Microalgae: Potential Uses on Pharmacology and Harmful Algae Bloom Control

09-Feb-2018 | Zerrifi, Soukaina El Amrani; El Khalloufi, Fatima ; Oudra, Brahim ; Vasconcelos, Vitor, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 55: Seaweed Bioactive Compounds against Pathogens and Microalgae: Potential Uses on Pharmacology and Harmful Algae Bloom Control Marine Drugs doi: 10.3390/md16020055 Authors: Soukaina Zerrifi Fatima El Khalloufi Brahim Oudra Vitor ...

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